Core D: Data Management and Analysis Core

核心D：数据管理与分析核心

• 批准号: 10555693
• 负责人: Gyungah Jun
• 金额: $ 30.1万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555693
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Asian; Authorization documentation; Biological Markers; Clinical; Clinical Data; Clinical Research; Collaborations; Collection; Communities; Consultations; Data; Data Analyses; Data Collection; Data Management Resources; Data Set; Database Management Systems; Databases; Dedications; Deposition; Genetic; Genetic Diseases; Genetic study; Genotype; Human Resources; Infrastructure; Language; Leadership; Life Style; Manuals; Methods; National Institute on Aging; Online Systems; Participant; Phenotype; Population; Preparation; Protocols documentation; Quality Control; Reporting; Research Design; Research Personnel; Resources; SNP array; Sampling; Scanning; Secure; Single Nucleotide Polymorphism; Site; Statistical Data Interpretation; Statistical Methods; Surveys; System; Training; analysis pipeline; analytical method; application programming interface; authority; central database; cohort; computerized data processing; data access; data acquisition; data dictionary; data management; data resource; data sharing; data storage site; design; ethnic diversity; genetic analysis; genome-wide; innovation; instrument; multi-ethnic; non-genetic; outreach; phenotypic data; racial diversity; recruit; repository; sample collection; screening; tool; web interface; web services

SUMMARY – CORE D Core D requires extensive data processing and management capabilities to generate high-quality, integrated, harmonized, and analysis-ready data, and also the ability to implement statistical methods and analysis tools. Core D aims to provide a platform for data management and sharing for all ACAD cores and projects, as well as facilitate internal and external scientific collaborations using the ACAD data. Core D specifically will 1) d evelop and maintain a centralized data management system for clinical data, lifestyle surveys, sample collection information, and prescreening and/or non-clinical data collection, 2) apply quality control protocols across all data and prepare analysis ready datasets for the Projects, 3) facilitate data access and sharing within and outside the ACAD community by providing infrastructure and expertise in data management, sharing, and analysis across all ACAD cores and projects, and 4) integrate external resources and provide analytic consultations by incorporating external data resources to expedite innovative scientific projects by ACAD investigators using ethnically diverse datasets. The Core D leadership and personnel will closely interact with the recruitment sites of the Administrative, B-HEARD (Outreach), Clinical, Biosample, and Training Cores for implementation of data collection protocols, data and sample analysis flow, and data sharing and management.

摘要 – 核心 D Core D 需要广泛的数据处理和管理能力来生成高质量、集成的、 协调一致且可供分析的数据，以及实施统计方法和分析工具的能力。 Core D 旨在为所有 ACAD 核心和项目提供数据管理和共享平台 使用 ACAD 数据促进内部和外部科学合作。核心 D 特别会 1) d 开发和维护临床数据、生活方式调查、样本的集中数据管理系统 收集信息，以及预筛选和/或非临床数据收集，2) 应用质量控制协议 跨所有数据并为项目准备分析就绪的数据集，3）促进数据访问和共享 并在 ACAD 社区之外提供数据管理、共享和数据方面的基础设施和专业知识 跨所有 ACAD 核心和项目进行分析，4) 集成外部资源并提供分析 通过整合外部数据资源进行磋商，以加快 ACAD 的创新科学项目 研究人员使用不同种族的数据集。 Core D 领导层和人员将与 行政、B-HEARD（外展）、临床、生物样本和培训核心的招聘地点 用于实施数据收集协议、数据和样本分析流程以及数据共享和 管理。