Core D: Data Management and Analysis Core

核心D：数据管理与分析核心

• 批准号: 10555693
• 负责人: Gyungah Jun
• 金额: $ 30.1万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555693
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Asian; Authorization documentation; Biological Markers; Clinical; Clinical Data; Clinical Research; Collaborations; Collection; Communities; Consultations; Data; Data Analyses; Data Collection; Data Management Resources; Data Set; Database Management Systems; Databases; Dedications; Deposition; Genetic; Genetic Diseases; Genetic study; Genotype; Human Resources; Infrastructure; Language; Leadership; Life Style; Manuals; Methods; National Institute on Aging; Online Systems; Participant; Phenotype; Population; Preparation; Protocols documentation; Quality Control; Reporting; Research Design; Research Personnel; Resources; SNP array; Sampling; Scanning; Secure; Single Nucleotide Polymorphism; Site; Statistical Data Interpretation; Statistical Methods; Surveys; System; Training; analysis pipeline; analytical method; application programming interface; authority; central database; cohort; computerized data processing; data access; data acquisition; data dictionary; data management; data resource; data sharing; data storage site; design; ethnic diversity; genetic analysis; genome-wide; innovation; instrument; multi-ethnic; non-genetic; outreach; phenotypic data; racial diversity; recruit; repository; sample collection; screening; tool; web interface; web services

SUMMARY – CORE D Core D requires extensive data processing and management capabilities to generate high-quality, integrated, harmonized, and analysis-ready data, and also the ability to implement statistical methods and analysis tools. Core D aims to provide a platform for data management and sharing for all ACAD cores and projects, as well as facilitate internal and external scientific collaborations using the ACAD data. Core D specifically will 1) d evelop and maintain a centralized data management system for clinical data, lifestyle surveys, sample collection information, and prescreening and/or non-clinical data collection, 2) apply quality control protocols across all data and prepare analysis ready datasets for the Projects, 3) facilitate data access and sharing within and outside the ACAD community by providing infrastructure and expertise in data management, sharing, and analysis across all ACAD cores and projects, and 4) integrate external resources and provide analytic consultations by incorporating external data resources to expedite innovative scientific projects by ACAD investigators using ethnically diverse datasets. The Core D leadership and personnel will closely interact with the recruitment sites of the Administrative, B-HEARD (Outreach), Clinical, Biosample, and Training Cores for implementation of data collection protocols, data and sample analysis flow, and data sharing and management.

摘要-核心D 核心D需要广泛的数据处理和管理能力，以生成高质量的、集成的、 协调和分析数据，以及实施统计方法和分析工具的能力。 Core D旨在为所有ACAD核心和项目提供数据管理和共享平台， 利用ACAD数据促进内部和外部科学合作。核心D具体将1） D 开发和维护一个集中的数据管理系统，用于临床数据、生活方式调查、样本 收集信息，以及预筛选和/或非临床数据收集，2）应用质量控制方案 所有数据，并为项目准备分析数据集，3）促进内部数据访问和共享 在ACAD社区之外，通过提供数据管理、共享和 分析所有ACAD核心和项目，以及4）整合外部资源并提供分析 通过整合外部数据资源，加快ACAD的创新科学项目， 研究人员使用不同种族的数据集。核心D的领导层和人员将与 行政、B-HEARD（外展）、临床、生物样本和培训核心的招募地点 用于实施数据收集协议、数据和样本分析流程以及数据共享， 管理