Integrating Home-Based Video Teleneuropsychology into Clinical Practice: Typical Versus Atypical Alzheimer's Disease
将家庭视频远程神经心理学融入临床实践:典型与非典型阿尔茨海默病
基本信息
- 批准号:10555271
- 负责人:
- 金额:$ 19.44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAlzheimer&aposs DiseaseAlzheimer&aposs disease patientAlzheimer&aposs disease related dementiaBlindedCOVID-19 outbreakCOVID-19 pandemicCaringClinicClinicalClinical TrialsCognitiveComplexConsentCrossover DesignDementiaDevelopmentDiagnosisDiagnosticDifferential DiagnosisEffectivenessElderlyEnrollmentEnsureEvaluationFutureGoalsHomeInterventionInterviewLanguageMeasuresMedicalMemoryMethodsModalityNerve DegenerationNeurologistNeurologyNeuropsychological TestsNeuropsychologyParticipantPatientsPersonsResearchResourcesStimulusSurveysTactileTest ResultTestingTravelUniversitiesValidationVisuospatialacceptability and feasibilityadjudicationclinical careclinical practicecognitive testingexperienceflexibilitygeographic barrierhealth care availabilityhealth care deliveryimprovedmild cognitive impairmentmulti-site trialolder patientpersonalized diagnosticspragmatic implementationpragmatic trialprimary care servicesremote administrationremote assessmentremote deliveryremote health carestakeholder perspectivesteleneuropsychologytesting servicesurban areavirtual
项目摘要
PROJECT SUMMARY/ABSTRACT
The overarching goal of this R21 application is to a) assess the feasibility and preliminary validity of home-
based delivery of teleneuropsychology (TeleNP) to patients with suspected Alzheimer's Disease (AD),
referred for cognitive assessments in a Neurology Clinic; and b) elucidate whether TeleNP is equivalent to
face-to-face evaluation (FF) for diagnostic adjudication of atypical versus typical AD. Although remote
administration of brief cognitive assessments has been shown to be a valid alternative to in-person testing with
typical, memory-predominant Mild Cognitive Impairment (MCI), these studies have focused primarily on the
remote delivery of testing services to a patient in a clinic rather than appraising feasibility and validity of remote
administration to a patient in their home. Moreover, prior studies have selectively focused on research
participants with uncomplicated presentations of MCI and AD dementia, raising questions as to the
generalizability of TeleNP to patients who are diagnostically challenging. In order to increase access to
neuropsychological assessments, improve the precision of neurodegenerative diagnoses, and ensure that
TeleNP is generalizable to complex presentations of AD and related disorders (ADRD), appraisal of the
feasibility and preliminary validity of home-based TeleNP in both typical and atypical AD is critically needed.
We will address the following Aims: Aim 1: Determine the validity of home-based video administration of
neuropsychological tests (TeleNP) for assessing AD; Aim 2: Evaluate the impact of home-based
TeleNP on the differential diagnosis of typical and atypical AD; Aim 3: Appraise the feasibility and
acceptability of TeleNP in the evaluation of AD patients. To accomplish these goals, we will conduct a pilot
clinical trial of two testing modalities, TeleNP versus FF, for delivery of neuropsychological evaluations.
Neurologist-referred patients with typical (i.e., memory-predominant; n=40) and atypical (i.e., complex and/or
non-memory predominant; n=40) presentations of possible AD will be enrolled in the study. Care partners of
participants will also be consented to the study and included in stakeholder surveys/interviews. Using a cross-
over design, all participants will undergo neuropsychological evaluations (clinical interview + Core Battery of
cognitive tests) in both modalities, approximately one month apart to account for potential practice effects.
Some cognitive tests are not readily adaptable to video-based delivery due to tactile/ physical stimuli; as such,
we will assess whether a Flexible Assessment (i.e., include additional tests with physical stimuli) in the FF
modality alters diagnostic conclusions. Finally, in an exploratory aim, we will identify stakeholder perspectives
of TeleNP that inform pragmatic implementation of remote neuropsychological evaluations. This pilot clinical
trial will provide an important platform for delineating the feasibility of implementing home-based TeleNP and
thereby prepare us for a future definitive pragmatic trial of TeleNP effectiveness across multiple clinics.
项目总结/摘要
这个R21应用程序的首要目标是a)评估家庭的可行性和初步有效性-
基于远程神经心理学(TeleNP)的传递给疑似阿尔茨海默病(AD)患者,
在神经病学诊所进行认知评估;和B)阐明TeleNP是否等同于
面对面评估(FF),用于诊断判定非典型AD与典型AD。虽然遥远
已证明进行简短的认知评估是面对面测试的有效替代方法,
典型的,以记忆为主的轻度认知障碍(MCI),这些研究主要集中在
远程递送测试服务到诊所中的患者,而不是评估远程递送的可行性和有效性。
给患者在家中进行治疗。此外,先前的研究选择性地集中在研究
参与者与MCI和AD痴呆的简单介绍,提出了问题,
TeleNP对诊断具有挑战性的患者的可推广性。为了增加获得
神经心理学评估,提高神经退行性疾病诊断的准确性,并确保
TeleNP可推广到AD和相关疾病(ADRD)的复杂表现,
基于家庭的TeleNP在典型和非典型AD中的可行性和初步有效性是迫切需要的。
我们将解决以下目标:目标1:确定家庭视频管理的有效性,
用于评估AD的神经心理学测试(TeleNP);目标2:评估基于家庭的
TeleNP在典型与非典型AD鉴别诊断中的应用目的3:评价TeleNP在AD鉴别诊断中的可行性,
TeleNP在AD患者评估中的可接受性。为了实现这些目标,我们将进行试点
两种测试模式的临床试验,TeleNP与FF,用于提供神经心理学评估。
神经科医生推荐的典型(即,记忆主导型; n=40)和非典型型(即,复杂和/或
非记忆占主导地位; n=40)的可能AD的表现将入组研究。关爱合作伙伴
参与者也将同意参加研究,并参加利益相关者的调查/访谈。使用十字架-
在设计中,所有参与者都将接受神经心理学评估(临床访谈+
认知测试),大约间隔一个月,以解释潜在的实践效果。
由于触觉/物理刺激,一些认知测试不容易适应基于视频的交付;因此,
我们将评估灵活评估(即,包括额外的物理刺激测试)
模态改变诊断结论。最后,在探索性目标中,我们将确定利益相关者的观点
的TeleNP,告知远程神经心理学评估的务实实施。该试点临床
试验计划将提供一个重要的平台,以探讨推行家居电话可携服务的可行性,
从而使我们为未来在多个诊所进行TeleNP有效性的最终实用性试验做好准备。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brianne Magouirk Bettcher其他文献
From Cognitive Neuroscience to Geriatric Neuropsychology: What Do Current Conceptualizations of the Action Error Handling Process Mean for Older Adults?
- DOI:
10.1007/s11065-009-9081-6 - 发表时间:
2009-01-27 - 期刊:
- 影响因子:5.000
- 作者:
Brianne Magouirk Bettcher;Tania Giovannetti - 通讯作者:
Tania Giovannetti
Brianne Magouirk Bettcher的其他文献
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{{ truncateString('Brianne Magouirk Bettcher', 18)}}的其他基金
Integrating Home-Based Video Teleneuropsychology into Clinical Practice: Typical Versus Atypical Alzheimer's Disease
将家庭视频远程神经心理学融入临床实践:典型与非典型阿尔茨海默病
- 批准号:
10370907 - 财政年份:2022
- 资助金额:
$ 19.44万 - 项目类别:
Investigating the Contribution of Peripheral versus Central Nervous System Immune Dysfunction to Cognitive Aging
调查周围神经系统免疫功能障碍与中枢神经系统免疫功能障碍对认知衰老的影响
- 批准号:
10061516 - 财政年份:2019
- 资助金额:
$ 19.44万 - 项目类别:
Investigating the Contribution of Peripheral versus Central Nervous System Immune Dysfunction to Cognitive Aging
调查周围神经系统免疫功能障碍与中枢神经系统免疫功能障碍对认知衰老的影响
- 批准号:
10320414 - 财政年份:2019
- 资助金额:
$ 19.44万 - 项目类别:
Investigating the Contribution of Peripheral versus Central Nervous System Immune Dysfunction to Cognitive Aging
调查周围神经系统免疫功能障碍与中枢神经系统免疫功能障碍对认知衰老的影响
- 批准号:
10534200 - 财政年份:2019
- 资助金额:
$ 19.44万 - 项目类别:
Investigating the Contribution of Peripheral versus Central Nervous System Immune Dysfunction to Cognitive Aging
调查周围神经系统免疫功能障碍与中枢神经系统免疫功能障碍对认知衰老的影响
- 批准号:
10736575 - 财政年份:2019
- 资助金额:
$ 19.44万 - 项目类别:
Investigating the Contribution of Peripheral versus Central Nervous System Immune Dysfunction to Cognitive Aging
调查周围神经系统免疫功能障碍与中枢神经系统免疫功能障碍对认知衰老的影响
- 批准号:
10190641 - 财政年份:2019
- 资助金额:
$ 19.44万 - 项目类别:
Advanced Methods to Measure Sleep Spindle Coupling as a Key Neuroprotective Component of Slow Wave Sleep
测量睡眠纺锤体耦合作为慢波睡眠关键神经保护成分的先进方法
- 批准号:
10386251 - 财政年份:2019
- 资助金额:
$ 19.44万 - 项目类别:
Investigating the Contribution of Peripheral versus Central Nervous System Immune Dysfunction to Cognitive Aging
调查周围神经系统免疫功能障碍与中枢神经系统免疫功能障碍对认知衰老的影响
- 批准号:
10547921 - 财政年份:2019
- 资助金额:
$ 19.44万 - 项目类别:
Cognitive and Neural Correlates of Inflammation in Healthy Older Adults
健康老年人炎症的认知和神经相关性
- 批准号:
8529440 - 财政年份:2012
- 资助金额:
$ 19.44万 - 项目类别:
Cognitive and Neural Correlates of Inflammation in Healthy Older Adults
健康老年人炎症的认知和神经相关性
- 批准号:
8353958 - 财政年份:2012
- 资助金额:
$ 19.44万 - 项目类别: