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The role of sexually dimorphic vasopressin in social behavior

性二态性加压素在社会行为中的作用

基本信息

批准号：
10557900
负责人：
Nicole Rigney
金额：
$ 2.73万
依托单位：
GEORGIA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-22 至 2023-06-21
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10557900
关键词：
Ablation Acute Adult Affect Aggressive behavior Anions Area Argipressin Behavior Behavior Disorders Behavioral Brain Brain region Cell physiology Cells Chemicals Chronic Communication Excision Exposure to Fellowship Female Functional disorder Genes Goals Grant Hypothalamic structure Incidence Investigation Lateral Maternal Behavior Mediating Mental disorders Modernization Morbidity - disease rate Motivation Mus Neuroanatomy Neurons Neuropeptides Neurotransmitters Opsin Output Partner in relationship Play Population Prevalence Publications Research Personnel Role Sex Differences Sex Differentiation Site Social Behavior Social Behavior Disorders Social Controls Social Functioning Social Interaction Source Steroids Structure of terminal stria nuclei of preoptic region Synapses System Techniques Testing Training Vasopressins Vertebrates Viral Virus autism spectrum disorder behavior test communication behavior experimental study genetic approach genetic manipulation knock-down male mind control nerve supply neural neural circuit neural network neuromechanism neuronal cell body neuroregulation optogenetics overexpression receptor sex sexual dimorphism sexual role small hairpin RNA social social communication social relationships training opportunity

项目摘要

Project Summary This project aims to understand the function of sex difference in the neural control of social behavior by focusing on the sexually dimorphic vasopressin system, where males have much higher vasopressin expression than females. Experiments proposed during the fellowship period will identify whether the sex difference in vasopressin innervation contributes to sex differences in the control of social behavior and communication. I will gain exceptional training in powerful genetic approaches that allow us to target vasopressin cells and the vasopressin gene specifically. The first aim tests whether excitation or inhibition of the sexually dimorphic vasopressin cells in the bed nucleus of the stria terminalis (BNST) affects social behavior differently in males and females. The second aim tests whether vasopressin is the key neuropeptide mediating sex-different effects on social communication observed in a previous study that ablated BNST vasopressin cells. This project will significantly enhance our mechanistic understanding of how the brain controls social behavior differently in males and females and may explain why many behavioral disorders show striking sex differences in morbidity. Although recently major advances have been made in understanding the neural basis of social behavior in adulthood, how such behavior is controlled differently in males and females is, by and large, unknown. This training grant will address these issues.

项目摘要本项目旨在了解性别差异在社会行为神经控制中的作用，重点是两性加压素系统，其中男性具有更高的加压素比女性的表情。在研究期间提出的实验将确定性别是否加压素神经支配的差异导致社会行为控制的性别差异，通信我将在强大的遗传学方法方面获得特殊的训练，加压素细胞和加压素基因。第一个目的是测试是否兴奋或抑制终纹床核（BNST）中的性二型加压素细胞影响社交功能，在男性和女性中的行为不同。第二个目的是测试加压素是否是关键的神经肽在先前的一项消融BNST的研究中观察到的对社会交往的性别差异影响加压素细胞这个项目将大大提高我们对大脑如何男性和女性控制社会行为的方式不同，这可能解释了为什么许多行为障碍表现为发病率的显著性别差异。虽然最近在理解这些问题上取得了重大进展，成年期社会行为的神经基础，这种行为在男性和女性中是如何不同地控制的基本上是未知的这项培训补助金将解决这些问题。