Advancing Alzheimer's Disease Communication and Recruitment Science among American Indians and Alaska Natives

项目摘要/摘要 阿尔茨海默病和相关痴呆症(ADRD)影响着550万美国人。世界上有多少人 预计到2050年，美国ADRD患者将增加到1600万人，除非进行预防性干预和有效 治疗方法被开发出来。尽管非西班牙裔白人的ADRD研究取得了进展，但人们对此知之甚少 关于ADRD在美洲印第安人和阿拉斯加原住民(AI/AN)人群中的流行率和风险因素。这 部分原因是人工智能/人工神经网络对ADRD研究的参与度较低。美国国家老龄和老年问题研究所 阿尔茨海默氏症协会呼吁增加少数族裔参与临床试验。然而， 在将AI/AN人群招募到ADRD临床研究中的努力中一直未能取得成功。互联网是一种 提供有关ADRD的信息并招募参与者参加临床研究的主要方法。人工智能/人工智能 经常使用互联网获取健康信息，但也报告说他们访问的网站缺乏文化 敏感度。要提高人工智能/人工智能对ADRD研究的参与度，关键是要了解人工智能/人工智能如何消费 并处理在线信息。这些信息可用于创建有效的沟通和招聘 ADRD临床研究的材料。在本K01中，我们将应用多方法方法来评估AI/ANS 处理和使用在线材料。利用这些信息，我们将创建文化定制的在线内容，以 教育AI/AN有关ADRD的知识，以促进他们加入ADRD研究。我们的具体目标是：1) 进行心理生理学测试和半结构化访谈，以表征视觉网站搜索模式， 客观测量的认知和情绪反应，关于ADRD和研究的知识，以及 对在线获取健康信息的偏好；2)创建针对文化定制的ADRD教育网站 AI/ANS提供研究机会并进行试点研究，以证明未来的可行性 随机对照试验；3)完成严格的培训计划，将申请者定位为 独立调查者和与服务不足的人群，特别是人工智能/人工智能/人工智能沟通的领导者。这 创新的应用程序提供了发现有关AI/ANS流程的关键信息的机会 信息和回应国家老龄研究所呼吁进行研究以更好地了解有效 招募少数群体参与ADRD研究和传播适当的健康信息的战略 对于不同的人群。

PROJECT SUMMARY/ABSTRACT Alzheimer’s disease and related dementias (ADRD) affects 5.5 million Americans. The number of people in the US with ADRD is expected to increase to 16 million by 2050 unless preventive interventions and effective treatments are developed. Despite advances in ADRD research among non-Hispanic Whites, little is known about the prevalence and risk factors for ADRD in American Indian and Alaska Native (AI/AN) populations. This is in part due to low participation of AI/ANs in ADRD research. The National Institute on Aging and the Alzheimer’s Association have issued calls for an increase in minority participation in clinical trials. However, success has been evasive in efforts to recruit AI/AN populations into ADRD clinical studies. The internet is a primary method for providing information about ADRD and recruiting participants into clinical studies. AI/ANs frequently use the internet for health information but also report that the websites they access lack cultural sensitivity. To increase AI/AN participation in ADRD research, it is critical to understand how AI/ANs consume and process online information. This information can be used to create effective communication and recruitment material for ADRD clinical studies. In this K01, we will apply a multi-method approach to assess how AI/ANs process and consume online material. Using this information, we will create culturally tailored online content to educate AI/ANs about ADRD to promote their enrollment into ADRD research. Our Specific Aims are to: 1) conduct psychophysiology testing and semi-structured interviews to characterize visual website search patterns, objectively measured cognitive and emotional responses, knowledge about ADRD and research, and preferences for accessing health information online; 2) create a culturally tailored educational ADRD website for AI/ANs that offers research opportunities and conduct a pilot study to demonstrate feasibility of a future randomized controlled trial; and 3) complete a rigorous training plan that will position the applicant as an independent investigator and leader in communication with underserved populations, especially AI/ANs. This innovative application provides an opportunity to discover critical information about how AI/ANs process information and answers the National Institute on Aging’s call for research to better understand effective strategies for recruiting minorities into ADRD research and communicating health messages that are appropriate for diverse populations.