Advancing Alzheimer's Disease Communication and Recruitment Science among American Indians and Alaska Natives

促进美洲印第安人和阿拉斯加原住民之间的阿尔茨海默病传播和招募科学

• 批准号: 10596112
• 负责人: Amanda D. Boyd
• 金额: $ 11.92万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596112
• 关键词: Acceleration; Adherence; Adult; Affect; Age; Aging; Alaska Native; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; American Indians; Asian population; Attention; Behavior; Clinical Research; Clinical Treatment; Clinical Trials; Cognitive; Communication; Communication Methods; Complement; Computers; Consumption; Cultural Sensitivity; Data; Data Collection; Development; Education; Elderly; Electromyography; Emotional; Enrollment; Eye Movements; Face; Funding; Future; Galvanic Skin Response; General Population; Goals; Grant; Guidelines; Health; Health Disparities Research; Health Policy; Healthcare; Heart Rate; Image; Imagery; Instruction; Internet; Interview; Knowledge; Measures; Mentors; Methods; Minority Participation; Minority Recruitment; National Institute on Aging; Not Hispanic or Latino; Outcome; Participant; Patient Recruitments; Patient Self-Report; Pattern; Persons; Pilot Projects; Population; Population Heterogeneity; Positioning Attribute; Prevalence; Process; Protocols documentation; Psychophysiology; Questionnaires; Race; Randomized; Randomized, Controlled Trials; Reaction; Reader; Reading; Reporting; Research; Research Methodology; Research Personnel; Resources; Respondent; Scanning; Self Assessment; Shapes; Site; Source; Structure; Surveys; Testing; Text; Training; Underserved Population; United States National Institutes of Health; Variant; Visual; Writing; career development; design; digital communication; digital technology; effective therapy; effectiveness trial; experience; falls; health communication; information seeking behavior; innovation; novel; preference; preventive intervention; primary outcome; randomized trial; recruit; recruitment science; research study; response; success; visual tracking; web site; willingness

PROJECT SUMMARY/ABSTRACT Alzheimer’s disease and related dementias (ADRD) affects 5.5 million Americans. The number of people in the US with ADRD is expected to increase to 16 million by 2050 unless preventive interventions and effective treatments are developed. Despite advances in ADRD research among non-Hispanic Whites, little is known about the prevalence and risk factors for ADRD in American Indian and Alaska Native (AI/AN) populations. This is in part due to low participation of AI/ANs in ADRD research. The National Institute on Aging and the Alzheimer’s Association have issued calls for an increase in minority participation in clinical trials. However, success has been evasive in efforts to recruit AI/AN populations into ADRD clinical studies. The internet is a primary method for providing information about ADRD and recruiting participants into clinical studies. AI/ANs frequently use the internet for health information but also report that the websites they access lack cultural sensitivity. To increase AI/AN participation in ADRD research, it is critical to understand how AI/ANs consume and process online information. This information can be used to create effective communication and recruitment material for ADRD clinical studies. In this K01, we will apply a multi-method approach to assess how AI/ANs process and consume online material. Using this information, we will create culturally tailored online content to educate AI/ANs about ADRD to promote their enrollment into ADRD research. Our Specific Aims are to: 1) conduct psychophysiology testing and semi-structured interviews to characterize visual website search patterns, objectively measured cognitive and emotional responses, knowledge about ADRD and research, and preferences for accessing health information online; 2) create a culturally tailored educational ADRD website for AI/ANs that offers research opportunities and conduct a pilot study to demonstrate feasibility of a future randomized controlled trial; and 3) complete a rigorous training plan that will position the applicant as an independent investigator and leader in communication with underserved populations, especially AI/ANs. This innovative application provides an opportunity to discover critical information about how AI/ANs process information and answers the National Institute on Aging’s call for research to better understand effective strategies for recruiting minorities into ADRD research and communicating health messages that are appropriate for diverse populations.

项目摘要/摘要 阿尔茨海默氏病和相关痴呆症（ADRD）影响了550万美国人。在 除非预防干预措施和有效 开发了治疗。尽管非西班牙裔白人在ADRD研究方面取得了进步，但鲜为人知 关于美洲印第安人和阿拉斯加本地人（AI/AN）人口的ADRD的患病率和风险因素。这 部分原因是AI/ANS参与ADRD研究。国家老化研究所 阿尔茨海默氏症协会发布了呼吁少数群体参与临床试验的呼吁。然而， 成功将AI/A A/A人群招募到ADRD临床研究方面已经逃避了。互联网是 提供有关ADRD和招募参与者的信息的主要方法。 ai/ans 经常使用互联网获取健康信息，但还报告说他们访问的网站缺乏文化 灵敏度。为了增加AI/A ADRD研究，重要的是要了解AI/ANS如何消费 并处理在线信息。这些信息可用于创建有效的沟通和招聘 ADRD临床研究的材料。在此K01中，我们将采用多方法方法来评估AI/ANS 流程和消费者在线材料。使用此信息，我们将创建经过文化量身定制的在线内容 教育AI/ANS关于ADRD，以促进他们参加ADRD研究。我们的具体目的是：1） 进行心理生理学测试和半结构化访谈，以表征视觉网站搜索模式， 客观地衡量认知和情感反应，对ADRD和研究的知识以及 在线访问健康信息的偏好； 2）创建一个文化量身定制的教育ADRD网站 AI/ANS提供研究机会并进行试点研究以证明未来的可行性 随机对照试验； 3）完成严格的培训计划，将申请人定位为 与服务不足的人群（尤其是AI/ANS）沟通的独立研究者和领导者。这 创新应用程序提供了一个机会，可以发现有关AI/ANS流程的关键信息 信息并回答美国国家老化呼吁进行研究的信息，以更好地理解有效 招募少数民族进入ADRD研究并传达适当的健康信息的策略 对于不同的人群。