Consortium of Research Advancement Facilities and Training

总结/摘要 为了实现精准营养，研究促进设施和培训联盟（CRAFT）正在 建议将建立新的研究设施，并加强现有的，确保国家的， COBRE资助的研究人员可以获得艺术设备和其他必要资源，以促进研究的进行 采用尖端技术的高质量、高影响力的研究。新的、新兴的和已建立的 核心包括CRAFT，包括表观基因组学，代谢组学，脂质组学，微生物组学，营养学， 代谢表型分析、显微镜/成像和生物信息学将在统一的 行政结构，每个核心的董事组成一个执行委员会， 每年进行外部评估并确定预算的优先次序。这种新的核心配置将允许更大的 资源灵活性和提高研究效率。在此，我们建议建立一个新的统计 分析，营养和饮食核心，并扩大表观基因组学，代谢组学，脂质组学，代谢 表型分析、显微镜/成像和生物信息学核心设施。教育、培训、获得 设备和咨询是或将随时提供给研究人员在大学在每一个这些 领域，通过高度成就的教师和他们的支持人员，博士后和初级专业知识 教师同事。执行委员会将聘请一名第三方专家来衡量和评估 每年评估每个CRAFT核心的有效性，以确保UH调查人员的相关性和价值。 CRAFT的目标是提供资源、专业知识、教育和培训， CRAFT提供的有价值的生物医学研究将产生下一代研究领导者 以及精准营养领域的导师，最终造福于夏威夷和太平洋地区的人民 通过改善健康结果和生活质量。为了实现这一目标，我们的目标是提供 最新的技术/设备（目标1）、教育和培训（目标2）以及基于咨询的专业知识 (Aim 3）支持表观基因组学、代谢组学、脂质组学、代谢表型分析等研究， 宏基因组学（微生物组），显微镜/成像和生物信息学。总的来说， CRAFT的资源和专业知识将大大扩大研究的方向和深度， 研究人员和合作团体，并提高他们的研究质量，从而定位他们， 成功地获得高影响力、同行评审出版物和外部赠款支持。通过与我们的 社区参与和外展核心，我们预计，在精密领域的研究活动 营养不仅与社区需求有关（例如，健康差距与缺乏 营养），而且还提供了一个协调一致的机制，以鼓励该地区的社区支持和教育 基础科学、临床和转化研究。因此，CRAFT是夏威夷独有的， 精准营养基金会对全国健康研究产生深远影响。

SUMMARY/ABSTRACT To enable Precision Nutrition, a Consortium of Research Advancement Facilities & Training (CRAFT) is proposed that will establish new research facilities and enhance existing ones, ensuring that state-of-the- art equipment and other essential resources are available to COBRE-funded researchers to facilitate the conduct of high-quality, high-impact research employing cutting-edge technologies. New, emerging, and established Cores comprising CRAFT that include Epigenomics, Metabolomics, Lipidomics, Microbiomes, Nutrition, Metabolic Phenotyping, Microscopy/Imaging, and Bioinformatics will be integrated under a unified administrative structure, with directors of each Core forming an Executive Committee that facilitates external evaluations and prioritizes budgets annually. This novel configuration of Cores will allow greater resource flexibility and improved efficiency of research. Herein, we propose to establish a new Statistical Analysis, Nutrition & Diet Core, and to expand Epigenomics, Metabolomics, Lipidomics, Metabolic Phenotyping, Microscopy/Imaging, and Bioinformatics Core Facilities. Education, training, access to equipment and consultation are or will be readily available to investigators at the University in each of these areas, through the expertise of highly accomplished faculty and their support staff, postdocs and junior faculty colleagues. The Executive Committee will contract a third-party expert to measure and evaluate the effectiveness of each of the CRAFT Cores annually to ensure relevance and value for UH investigators. The goal of the CRAFT is to provide resources, expertise, education and training for the advancement of meritorious biomedical research provided by the CRAFT will produce the next generation of research leaders and mentors in the field of Precision Nutrition to ultimately benefit the people of Hawaii and the Pacific region through improvement of health outcomes and quality of life. To achieve this goal, we aim to provide access to the latest technologies/equipment (Aim 1), education and training (Aim 2), and consultation-based expertise (Aim 3) altogether supporting research in Epigenomics, Metabolomics, Lipidomics, Metabolic Phenotyping, Metagenomics (Microbiomes), Microscopy/Imaging, and Bioinformatics. Collectively, the availability of the CRAFT resources and expertise will substantively expand the direction and depth of research conducted by researchers and collaborating groups, and increase the quality of their research, thus positioning them to successfully attain high-impact, peer-reviewed publications and external grant support. By working with our Community Engagement and Outreach Core, we anticipate that the research activities in the field of Precision Nutrition will not only be relevant to community needs (e.g., health disparities that are related to deficiencies in nutrition) but also provide a concerted mechanism to encourage community support and education in the area of basic science, clinical, and translational research. Thus, the CRAFT is unique to Hawaii and is an essential foundation for Precision Nutrition with far-reaching implications to health research nationally.