CAR Therapy for T Cell Malignancies

T 细胞恶性肿瘤的 CAR 疗法

• 批准号: 102571
• 金额: $ 214.33万
• 依托单位: AUTOLUS LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=102571
• 关键词: CAR; Therapy; Cell; Malignancies

T-cells are immune cells in our bodies whose function is to "seek and destroy" cells which are infected byviruses. Since T-cells actively move around our bodies looking for infected cells, medical science has long triedto make these T-cells attack cancer cells. Because cancer cells usually come from normal cells in our bodieswithout virus infections, T-cells don't normally attack them. By taking T-cells from a blood sample and "re-programming" them using genetic engineering, medical science has found a way of using T-cells to attackcancer. These engineered T-cells are called "CAR T-cells" and they can be given back to the patient as a drip.Once back in the patient, they "seek and destroy" cancer cells as if they were virus-infected cells. CAR T-cellsseem to be a very effective new form of cancer treatment. Cancers can come from any cells in our bodies. EvenT-cells can become cancer cells and some of these cancers are called T-cell lymphomas. This project deals withthe particular problem of CAR T-cells attacking T-cell lymphomas. Scientists working on this project have founda way of making CAR T-cells that attack the cancerous T-cells but leave plenty of normal healthy T-cells alone.

T细胞是我们体内的免疫细胞，其功能是“寻找并摧毁”被病毒感染的细胞。由于T细胞活跃地在我们的身体周围移动，寻找受感染的细胞，因此医学科学长期以来一直试图使这些T细胞攻击癌细胞。因为癌细胞通常来自我们体内没有病毒感染的正常细胞，T细胞通常不会攻击它们。通过从血液样本中提取T细胞，并利用基因工程对它们进行“重新编程”，医学科学已经找到了一种利用T细胞攻击癌症的方法。这些工程化的T细胞被称为“CAR T细胞”，它们可以作为点滴输回患者体内。一旦回到患者体内，它们就像病毒感染的细胞一样“寻找并摧毁”癌细胞。CAR-T细胞似乎是一种非常有效的癌症治疗新形式。癌症可能来自我们身体中的任何细胞。T细胞可以变成癌细胞，其中一些癌症被称为T细胞淋巴瘤。该项目涉及CAR T细胞攻击T细胞淋巴瘤的特殊问题。从事这个项目的科学家们已经找到了一种制造CAR T细胞的方法，这种细胞可以攻击癌性T细胞，但不会伤害大量正常的健康T细胞。