Innovative Textile Reinforced Anatomical Total Meniscus Replacement for the Knee Joint

鉴于半月板在膝关节负荷传递和关节稳定性方面的关键作用，半月板损伤是最常见的骨科手术干预，半月板相关手术占所有膝关节手术的50%。尽管如此，对于严重受损的半月板，目前的治疗标准仍然是部分或全部半月板切除术，治疗选择非常有限。半月板切除术是一种外科手术，现在被认为是骨关节炎（OA）的主要危险因素。骨关节炎是一种慢性衰弱疾病，在英国有400多万人受到影响，估计有50%的半月板部分切除术患者因此被诊断为OA。Orthonika在BMC项目的支持下，为了解决这一医疗保健挑战，我们开发了第一个人工合成全替代半月板，它精确地模仿了半月板组织的自然结构，复制了自然半月板的“结构-功能”，提供了一种耐用的植入物，可以以最小的侵入植入，并安全地固定在骨骼上，以承受严苛的身体活动——这是目前严重半月板损伤患者无法获得的一种选择。该解决方案填补了目前姑息治疗实践和全膝关节置换术之间的临床护理差距，恢复功能并预防OA发作。

Given the critical role the menisci play in the knee joint in terms of load transmission and joint stability, Meniscus injury is the most frequent orthopaedic surgical intervention with meniscus -related operations accounting for up to 50% of all knee surgeries. Despite this prevalence, for severely damaged menisci today’s standard of care is still partial or total meniscectomy with extremely limited treatment options. Removal of the meniscus is a surgical procedure that is now well understood to be a major risk factor for osteoarthritis (OA) a chronic and debilitating condition that effects more than 4 million people in the UK , with an estimated 50% of partial meniscectomy patients being diagnosed with OA as a result. Orthonika, with support through the BMC programme, aim to address this healthcare challenge with the development of the first synthetic total replacement meniscus that accurately mimics the natural structure of meniscal tissue replicating the ‘structure-function’ of the natural meniscus to provide a durable implant that can be implanted with minimal invasion and fixed securely to the bone to withstand the rigour of physical activity - an option not currently available to patients with severe meniscus injury. The solution fulfils a clinical care gap between current palliative care practices and total knee replacement, restoring function and preventing the onset of OA.