课题基金 / 基金详情

NITROXIDE LABELED HEMOGLOBIN AS A BLOOD SUBSTITUTE

NITROXIDE LABELED HEMOGLOBIN AS A BLOOD SUBSTITUTE
氮氧化物标记的血红蛋白作为血液替代品
批准号:
2231991
负责人:
Carleton Hsia
金额:
$9.84万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1995
资助国家:
美国
项目状态:
已结题
起止时间:
1995-03-01 至 1995-08-31

项目摘要

项目成果

Carleton Hsia的其他基金

相关文献

中文摘要
翻译
一些生物制药公司已经成功地采取了
英文摘要
A number of biopharmaceutical companies have successfully taken hemoglobin-based oxygen carriers (HBOC) into phase I clinical trial. However, transfusions have been limited to low dosage levels due to observed hypertensive and vasoconstrictive effects at high dosage levels in pre- c1inical animal studies. This proposal deals with the current HBOC's failure to have an oxidant detoxification system similar to the one which is intrinsic to the red blood cells it intends to substitute. This research plan intends to modify a high- quality HBOC, which is currently in clinical trials, to demonstrate that stable nitroxide free radicals can be used to perform an oxidant detoxification function. If the research is successful, then the groundwork would established for a second generation red blood cell substitute which could successfully commercialized.
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会议论文
Polynitroxylated Pegylated Hemoglobin for Traumatic Brian Injury Resuscitation
  • 批准号:
    8057277
  • 项目类别:
  • 资助金额:
    $30.0万
  • 财政年份:
    2011
  • 负责人:
    Carleton Hsia
  • 依托单位:
Polynitroxylated Pegylated Hemoglobin for Traumatic Brian Injury Resuscitation
  • 批准号:
    8618296
  • 项目类别:
  • 资助金额:
    $95.71万
  • 财政年份:
    2011
  • 负责人:
    Carleton Hsia
  • 依托单位:
Polynitroxylated Pegylated Hemoglobin for Traumatic Brian Injury Resuscitation
  • 批准号:
    8250332
  • 项目类别:
  • 资助金额:
    $29.41万
  • 财政年份:
    2011
  • 负责人:
    Carleton Hsia
  • 依托单位:
Polynitroxylated Pegylated Hemoglobin for Traumatic Brian Injury Resuscitation
  • 批准号:
    8666673
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    2011
  • 负责人:
    Carleton Hsia
  • 依托单位: