STEREOTACTIC BIOPSY OF BREAST LESIONS USING CCD IMAGING

拟议中的项目将联合收割机基础科学成像研究与 前瞻性临床试验，以检查立体定向乳腺针是否 电子成像引导下的活检（SBNB）可用于诊断和 管理未触及乳房异常的患者。 我们已经开发出一种 使用电荷耦合器件的数字立体定向乳房X线摄影系统 (CCD)as the image图像receptor受体. 该系统生成高分辨率数字 在3-5秒内获得乳房图像，允许活检针的位置 迅速核实。因此，执行的准确性和效率 对触诊不清的乳腺病变进行经皮活检。 数字成像系统已经组装好，我们目前正在执行 基础科学实验，以评估的基本特征， 系统，包括调制传递函数，信噪比， 光子注量、辐射剂量和探测量子效率。 接下来 系统将在临床上用于对400名患者进行SBNB， 不可触及的乳腺病变。 手术只会在那些 患有SBNB的癌症阳性患者。 阴性者 SBNB将保守管理。紧接着是乳房X光检查 每半年进行一次身体检查，持续两年。 的任何变化 病变将促使通过针或手术活检进行重新评估。 经过两 年的密切随访，患者将恢复到常规乳腺癌 监视 最后，我们将评估SBNB作为替代品的成本效益 在乳腺癌的评估和管理中， 疾病

The proposed project will combine basic science imaging research with a prospective clinical trial to examine whether stereotactic breast needle biopsy (SBNB), guided by electronic Imaging, can be used to diagnose and manage patients with nonpalpable breast abnormalities. We have developed a digital stereotactic mammography system that uses a charge-coupled device (CCD) as the image receptor. This system generates high resolution digital breast images in 3-5 seconds, allowing the position of a biopsy needle to be rapidly verified. Thus, the accuracy and efficiency of performing percutaneous biopsy of nonpalpable breast lesions will be enhanced. The digital imaging system is now assembled and we currently are performing basic science experiments to assess the fundamental characteristics of the system, including modulation transfer function, signal to noise ratio, photon fluence, radiation dose and detective quantum efficiency. Next, the system will be used clinically to perform SBNB on 400 patients with nonpalpable breast lesions. Surgery will be performed only on those patients with a SBNB that is positive for cancer. Patients with negative SBNBs will be managed conservatively. and closely followed with mammography and physical examination every six months for two years. Any change in the lesion will prompt re-evaluation by needle or surgical biopsy. After two years of close follow-up, patients will return to routine breast cancer surveillance. Finally, we will evaluate the cost effectiveness of SBNB as a substitute for surgical breast biopsy in the evaluation and management of breast disease.