X RAY MICROTOMOGRAPHY MEASUREMENTS IN BONE SPECIMENS

三维X射线计算机断层成像技术的研究 显微分辨率，或显微断层扫描，这将建立技术 提出了一种测量小型医学样品中矿物密度的方法。 的 该项目的总体目标是展示精确 重建小样本（2mm3）的骨密度，分辨率为 5微米。 值得注意的是，一个完整的三维密度测量将与 数据记录在2563数组中。 X射线成像非常适合于骨测量，因为有机软X射线成像是非常适合于骨测量的。 组织相对透明，矿物材料相对 不透明 建议的方法将针对检查矿物密度 在单个骨小梁内的复合材料中。 复杂的3D 骨小梁内存在不同的骨密度模式， 在解释与骨生长和骨相关的现象中的意义 重塑 拟议的研究将在现有的实验室进行， 专门的微焦点X射线源。 基于对 仪器性能，我们将修改X射线源，改变X射线 探测器，并开发新的数据重建软件，以实现我们的 绩效目标。 拟议的系统将具有不 可从光学显微镜或电子显微镜系统获得， 提供了一个数量级的性能改善， 当前的X射线显微断层摄影系统。 拟议系统的能力 直接测量完整样本的三维特性 对于骨的评估具有特别的价值 材料

Research on three-dimensional (3D) x-ray computed tomography with microscopic resolution, or microtomography, which will establish techniques to measure mineral density in small medical specimens is proposed. The overall goal of this project is to demonstrate the ability to precisely reconstruct the bone density of small (2mm3) specimens with a resolution of 5 microns. Notably, a complete 3D measurement of density will be made with data recorded in a 2563 array. X-ray imaging is well suited for bone measurements since organic soft tissues are relatively transparent and mineral materials are relatively opaque. The proposed methods will be directed at examining mineral density in the composite material within individual bone trabeculae. Complex 3D patterns of different bone density exist within trabeculae and have significance in explaining phenomena associated with bone growth and bone remodeling. The proposed research will be conducted in an existing laboratory using a specialized microfocus x-ray source. Based on a theoretical description of instrument performance, we will modify the x-ray source, change the x-ray detector, and develop new data reconstruction software to achieve our performance goals. The proposed system will have capabilities not available from light microscopy or electron microscopy systems and will provide an order of magnitude improvement in performance relative to current x-ray microtomography systems. The ability of the proposed system to directly measure the three-dimensional properties of an intact specimen without sectioning is of particular value for the evaluation of bone material.