PROSTATE CANCER IN RELATION TO VASECTOMY

最近对前列腺癌的研究表明，与前列腺癌相关的风险增加 做过输精管结扎术。中年人群前列腺癌发病率调查 华盛顿州西部的男性比过去增加了约60% 十年，而输精管结扎术是一种广泛使用的避孕方法 地理区域。如果最近研究的发现得到证实，这一点 可能代表着一个重大的公共卫生问题。该计划的主要目标是 建议的研究是确定输精管结扎术是否与 增加前列腺癌的风险，并评估是否有 输精管结扎术可能有潜在影响的证据。 为了研究输精管结扎术与前列腺癌的关系，我们 建议对700例病例和700例病例进行以人群为基础的病例对照研究 控制。符合条件的患者将是符合条件的40-男性 1993年1月1日至1993年1月1日期间被诊断为前列腺癌 1996年12月31日，是西北部金县的居民 华盛顿州。病例将通过西雅图-普吉特进行查明 健全的SEER癌症登记处。控制将通过随机方式确定 数字拨号，并将根据年龄匹配频率(相同的5年 组)和居住地县。研究对象将在#年接受采访 人。将获得有关输精管结扎术历史的信息， 生殖和性史，病史，人口统计变量， 以及健康行为，如吸烟和使用 早期发现前列腺癌的筛查程序。数据 分析将包括描述性、分层和多变量分析。 与输精管结扎术相关的前列腺癌的相对风险为 估计，在考虑了潜在的混淆影响后 其他暴露变量。

Recent studies of prostate cancer suggest an enhanced risk associated with prior vasectomy. The incidence of prostate cancer in middle-aged men in western Washington has increased by about 60% over the past decade, and vasectomy is a widely used method of contraception in this geographic area. If findings from recent studies are confirmed, this could represent a major public health problem. The primary aims of the proposed study are to determine whether or not vasectomy is related to an increased risk of prostate cancer, and to assess whether there is evidence of a possible latent effect of vasectomy. To study the relationship between vasectomy and prostate cancer, we propose a population-based case-control study of 700 cases and 700 controls. Eligible cases will be men 40-64 years of age who are diagnosed with incident prostate cancer between January 1, 1993 and December 31, 1996 and who are residents of King county in northwestern Washington State. Cases will be ascertained through the Seattle-Puget Sound SEER Cancer Registry. Controls will be identified through random digit dialing, and will be frequency matched to cases on age (same 5-year group) and county of residence. Study subjects will be interviewed in person. Information will be obtained on history of vasectomy, reproductive and sexual history, medical history, demographic variables, and health behaviors such as smoking and the prevalence of use of screening procedures for the early detection of prostate cancer. Data analysis will include descriptive, stratified, and multivariate analyses. The relative risk of prostate cancer in relation to vasectomy will be estimated, after accounting for the potential confounding effects of other exposure variables.