ASSESSMENT OF OVARIAN CANCER BY PET USING F-18-FDG

使用 F-18-FDG 通过 PET 评估卵巢癌

基本信息

  • 批准号:
    2100210
  • 负责人:
  • 金额:
    $ 17.79万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1993
  • 资助国家:
    美国
  • 起止时间:
    1993-09-30 至 1996-09-29
  • 项目状态:
    已结题

项目摘要

Positron Emission Tomography (PET) using F-18-FDG offers the opportunity to assess the extent of ovarian cancer throughout the abdominopelvic cavity for initial staging, and should be most useful as a routine follow-up test for possible recurrent tumor. Dynamic F-18-FDG PET studies were done in 20 patients at the time of initial diagnosis and staging or when recurrent tumor was suspected. Pet results were compared to Computed Tomography (CT) and surgical findings. Those preliminary data suggest for PET a 91% sensitivity, 75 % specificity and a positive predictive accuracy of 86%; for CT, sensitivity and specificity were 83.03% and 50% respectively. The data also indicate that dynamic data acquisition and time activity curve analysis enhance the diagnostic potential of F-18-FDG PET studies of the pelvis and abdomen. The long-term objective of this project is to validate the sensitivity and accuracy of F-18-FDG in localizing 1 ovarian cancer and metastatic abdominopelvic tumor activity for initial staging, monitoring of treatment, detection of recurrent tumor and guided biopsies. Specific aims are: (1) to further substantiate the high predictive accuracy of F- 18-FDG PET; (20 to determine the limitations of spatial resolution of the technique; (3) to correlate dynamic metabolic PET information with tumor nuclear grade and DNA flow cytometry proliferation indices; (40 to develop a method of parametrically imaging the slopes (accumulation rates) of the FDG uptake curves rather than the summation of accumulated activity (counts/pixel/sec), and (50 to determine whether F-18-FDG PET could assist in evaluating treatment response. Patients with suspected ovarian cancer will be selected for this study. They will have a complete workup for ovarian cancer according to a standard ACS guidelines. Dynamic F-18-FDG PET scans of the pelvis and abdomen and static "whole body' scans of the torso will be done prior to biopsy/hysterectomy, in mid-cycle of chemo- and/or radiation therapy, and at time of suspected recurrent tumor. CT and MRI scans will be obtained concomitantly. PET data analysis will include calculation of standardized uptake values (SUVs), time activity curve (TAC) and graphic Patlak analysis. Each patient will be treated by appropriate measures, including biopsy and/or surgery, combined with radiation therapy or chemotherapy. Tumor recurrence (proven by biopsy/histology) and patient survival are the standard against which the predictive value of F-18-FDG PET and flow cytometry will be measured.
使用F-18-FDG的正电子发射断层扫描(PET)提供了机会 评估卵巢癌在整个腹盆腔的范围 空洞用于初始阶段,应该是最有用的例程 对可能复发的肿瘤进行随访检测。动态F-18-FDG PET 在最初诊断时对20名患者进行了研究, 分期或怀疑肿瘤复发。将PET结果进行比较 计算机断层扫描(CT)和手术所见。那些初步的 数据显示,PET的敏感性为91%,特异性为75%,阳性率为 预测准确率为86%;对于CT,敏感性和特异性分别为 分别为83.03%和50%。该数据还指示动态数据 采集和时间活动曲线分析增强了诊断 盆腔和腹部的F-18-FDG PET研究的潜力。 该项目的长期目标是验证敏感性 F-18-FDG对1例卵巢癌及转移瘤定位的准确性 腹盆腔肿瘤活动性的初步分期、监测 治疗、肿瘤复发的检测和引导下的活检。特定的 目的是:(1)进一步证实F-1的高预测准确性 18-FDG正电子发射计算机断层扫描;(20以确定 技术;(3)动态代谢PET信息与肿瘤的关联 核分级和DNA流式细胞术增殖指数;(40~ 开发一种对坡度(累积)进行参数成像的方法 速率)而不是累积摄取曲线的总和 活动(计数/像素/秒)和(50以确定F-18-FDG PET是否 可以帮助评估治疗反应。 疑似卵巢癌的患者将被选为这项研究。 他们将对卵巢癌进行一次全面的检查,根据一项 标准的ACS指南。动态F-18-FDG骨盆和骨盆PET扫描 腹部和躯干的静态“全身”扫描将在 活检/子宫切除术,在化疗和/或放射治疗的中期,以及 在疑似肿瘤复发时。将进行CT和MRI扫描 随之而来的。PET数据分析将包括计算 标准化摄取值(SUV)、时间活动曲线(TAC)和图形 帕特拉克分析。 每个病人都会接受适当的治疗,包括活组织检查。 和/或手术,结合放射治疗或化疗。肿瘤 复发(经活检/组织学证实)和患者存活率是 F-18-FDG PET和FLOW预测价值的标准 将测量细胞计数。

项目成果

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KARL F HUBNER其他文献

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{{ truncateString('KARL F HUBNER', 18)}}的其他基金

ASSESSMENT OF OVARIAN CANCER BY PET USING F-18-FDG
使用 F-18-FDG 通过 PET 评估卵巢癌
  • 批准号:
    3203386
  • 财政年份:
    1993
  • 资助金额:
    $ 17.79万
  • 项目类别:
ASSESSMENT OF OVARIAN CANCER BY PET USING F-18-FDG
使用 F-18-FDG 通过 PET 评估卵巢癌
  • 批准号:
    2100211
  • 财政年份:
    1993
  • 资助金额:
    $ 17.79万
  • 项目类别:
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