Role of R-loops and double R-loops in genome organisation and transcription

R 环和双 R 环在基因组组织和转录中的作用

• 批准号: DP200101894
• 负责人: A/Prof Tamas Fischer
• 金额: $ 35.1万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101894
• 关键词: Role; loops; double; genome; organisation

The majority of our genome is converted to an extensive network of non-protein-coding RNA molecules (ncRNAs), but the function of these ncRNAs is unknown. This project aims to identify and determine the mechanism of action of nuclear ncRNA networks with a particular focus on nuclear ncRNAs that form RNA-DNA hybrids with the genomic DNA. These studies have the potential to lead to ground-breaking discoveries in our understanding of genome organisation and the mechanism of transcription control, and might provide an entirely new tool-box to manipulate genome function. This should provide significant benefits to efforts to develop innovative biotechnology and genome editing technologies in plants and animals.

我们基因组的大部分被转化为广泛的非蛋白质编码RNA分子（ncRNA）网络，但这些ncRNA的功能尚不清楚。该项目旨在识别和确定核ncRNA网络的作用机制，特别关注与基因组DNA形成RNA-DNA杂交的核ncRNA。这些研究有可能在我们对基因组组织和转录控制机制的理解方面带来突破性的发现，并可能提供一个全新的工具箱来操纵基因组功能。这将为在植物和动物中开发创新生物技术和基因组编辑技术的努力带来重大利益。