ANTIBODY INTERVENTION IN COCAINE ADDICTION

目前尚无可靠的可卡因药物治疗方法。 上瘾。另一种方法是阻止可卡因进入 由中枢神经系统产生抗可卡因抗体。这个 这项研究的目的是确定一种主动的 预防可卡因成瘾复发的免疫接种方法。可卡因 或者可卡因的衍生品将被用来使限定的载体半衰期。这些 结合物将用于免疫小鼠。如果高滴度可卡因特异 可以产生抗体来阻断对可卡因的毒性作用 挑战表明，通过免疫激发的抗体可以阻断中枢神经系统 介导的可卡因的再强化特性。定义的能力 改变动物模型中自我成瘾的结合免疫将是 在第二阶段研究。如果在动物模型中证明了有效性， 使用已定义的结合物的免疫可与 当前药物滥用治疗方案的预防能力 人类的可卡因成瘾在3-4年内复发。

Currently there are no reliable pharmacologic treatments for cocaine addiction. An alternate approach is to block access of cocaine to the central nervous system by the generation of anti-cocaine antibody. The goal of this research is to determine the feasibility of an active immunization approach to prevent relapse in cocaine addiction. Cocaine or cocaine derivatives will be used to haptenate defined carriers. These conjugates will be used to immunize mice. If high titer cocaine-specific antibody can be generated which blocks toxic effects upon cocaine challenge it suggests antibody elicited via immunization can block CNS mediated re-inforcing properties of cocaine. The ability of defined conjugate immunization to alter self-addiction in animal models will be studied in Phase II. Provided efficacy in animal models is demonstrated, immunization with defined conjugates can be tested in concert with current substance abuse treatment programs for its ability to prevent relapse in cocaine addiction in humans within 3-4 years.