DEVELOPMENT OF THE COTTON RAT AS AN ANIMAL MODEL

棉花鼠动物模型的开发

• 批准号: 2283973
• 负责人: GREGORY A. PRINCE
• 金额: $ 7.5万
• 依托单位: VIRION SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-02-01 至 1995-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2283973
• 关键词: antiantibody; biomaterial development /preparation; cross immunity; disease /disorder model; enzyme linked immunosorbent assay; gel filtration chromatography; immunoelectrophoresis; immunofluorescence technique; immunoglobulin isotypes; inbreeding; laboratory mouse; laboratory rabbit; laboratory rat; method development; monoclonal antibody; secretory protein

The cotton rat has been used in biomedical research since 1937, when it became the first small animal model of endemic typhus. Since then, it has been shown to be susceptible to infection by a remarkably wide spectrum of human and rodent pathogens. Of greatest current interest is its use as a model of human respiratory syncytial virus, parainfluenza virus type 3 and adenoviruses; of gene therapy of cystic fibrosis and alpha-1-antitrypsin deficiency; of filariasis; of pineal gland research; and of environmental toxicity. Use of the cotton rat, however, has been severely restricted due to lack of a commercial source of animals, an inbred cotton rat and immunologic reagents. Virion Systems, Inc. now provides inbred cotton rats commercially. The development of the reagents proposed in this grant application will greatly increase the utilization of the cotton rat as a model for a wide spectrum of human diseases.

自1937年以来，棉花大鼠一直在生物医学研究中使用 成为第一个流行斑疹伤寒的小动物模型。 从那以后，它 已证明很容易受到宽宽的感染 人类和啮齿动物病原体的频谱。 当前最大的兴趣是 它用作人类呼吸道合胞病毒的模型，Parainfluenza 病毒3型和腺病毒；囊性纤维化和 α-1-抗抗蛋白酶缺乏症；丝虫病；松果腺研究； 和环境毒性。 但是，使用棉鼠已经 由于缺乏动物的商业来源而受到严格限制， 近交棉大鼠和免疫学试剂。 Virion Systems，Inc。现在 商业上提供近交棉花大鼠。 发展 本赠款申请中提出的试剂将大大增加 利用棉鼠作为广泛人类的模型 疾病。