Antimicrobial silver sulphate loaded foam product safety testing problem

抗菌硫酸银负载泡沫产品安全检测问题

• 批准号: 105577
• 金额: $ 4.62万
• 依托单位: T.J.SMITH AND NEPHEW,LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=105577
• 关键词: Antimicrobial; silver; sulphate; loaded; foam

Advanced dressing products providing antimicrobial properties can improve healing rates, alleviating suffering, and ongoing healthcare costs. Some wounds represent more clinically severe (acute) situations such as large area burns/scalds or significant wounds on patients less able to fight off infections. In such situations, high risk of wound infection represents risk to life, necessitating the use of premium dressing products with powerful antimicrobial properties. Such products carry higher expense (both manufacture and end-user costs), but their use is justifiable to reduce mortality rates in high-risk situations.There is market demand for a more moderate-cost antimicrobial wound dressing product, intended for use in sub-acute, but hard to heal wounds, where the risk of chronic infection leading to longer term wound care is significant. Specifically, there is market-pull for a polyurethane foam product employing a silver-based antimicrobial action. The improved wound dressing product that this work relates to, is designed to directly address this market need by providing a line-development of our existing polyurethane foam-based product family.The innovative nature of the antimicrobial product must be well understood in terms of its compatibility with living tissue and its overall safety. Full understanding of these characteristics requires analysis of the physical and chemical nature of the product as may be expected from intended use. The scientific analytical methods required to obtain this information are not available off-the-shelf and A4I funding will allow us to identify and access the most appropriate cutting-edge analytical expertise and methods provided within the UK national measurement system.

具有抗菌性能的高级敷料产品可以提高愈合率，减轻痛苦和持续的医疗成本。一些伤口代表临床上更严重（急性）的情况，如大面积烧伤/烫伤或患者的严重伤口，无法抵抗感染。在这种情况下，伤口感染的高风险意味着生命风险，因此需要使用具有强大抗菌性能的优质敷料产品。这类产品费用较高（制造和最终用户成本），但它们的使用对于降低高风险情况下的死亡率是合理的。市场需要成本更适中的抗微生物伤口敷料产品，用于亚急性但难以愈合的伤口，其中慢性感染导致长期伤口护理的风险很大。具体地，对于采用基于银的抗微生物作用的聚氨酯泡沫产品存在市场拉动。这项工作涉及的改进的伤口敷料产品，旨在通过提供我们现有的聚氨酯泡沫基产品系列的生产线开发来直接满足这一市场需求。必须充分理解抗菌产品的创新性质，即其与活组织的相容性及其整体安全性。要充分了解这些特性，需要分析产品预期用途的物理和化学性质。获得这些信息所需的科学分析方法是现成的，A4 I资金将使我们能够确定和获得英国国家测量系统内提供的最合适的尖端分析专业知识和方法。