TREATMENT OF SENILE OSTEOPOROSIS

此请求的目的是帮助候选人发展为 一位独立的老年医学临床研究员和教师。这个 临床研究的必要技能将在以下情况下发展 一名高级调查员和他的小组的密切监督。这个 候选人将发展骨质疏松症研究和临床方面的专业知识 涉及老年人的审判。主要项目将是开展一项 随机、双盲、安慰剂对照试验 骨质疏松。这项研究的目的是确定一部小说的价值 老年慢性阻塞性肺疾病的药物治疗 骨质疏松。更具体地说，候选人将调查 以柠檬酸钙的形式补充钙的功效，以及 以缓释氟化钠形式存在的氟化物 65岁以上女性保留骨小梁的骨量 皮质骨。受试者将被随机分为两组。入院的病人 A组给予缓释氟化钠和柠檬酸钙。 B组患者将接受安慰剂和柠檬酸钙。重要 结果测量包括骨密度、骨折发生率、功能状态、 和不良影响。其他调查领域包括 Werner综合征合并骨质疏松症的特点及治疗 老年人骨质疏松症的病理生理学。教学目标 包括继续发展一所学术疗养院用于医疗 学员和住院医师培训。最终，候选人将会有所帮助 开发和建立跨越本科和大学的老年病学课程 研究生水平。大学、Parkland纪念医院和 达拉斯犹太老人之家提供的临床环境反映了 老年人中有代表性的人群，即男性和女性 广泛的种族和社会经济背景。此环境充当 教学和开展老龄化研究的理想环境。

The purpose of this request is to aid the development of the candidate as an independent clinical investigator and teacher of geriatrics. The necessary skills of clinical investigation will be developed while under the close supervision of a senior investigator and his group. The candidate will develop expertise in osteoporosis research and clinical trials involving older persons. The major project will be to carry out a randomized, double blind, placebo controlled trial for the treatment of osteoporosis. The aim of the study is to ascertain the value of a novel pharmacologic approach in the treatment of elderly individuals with osteoporosis. More specifically, the candidate will investigate the efficacy of supplemental calcium in the form of calcium citrate, and fluoride in the form of slow release sodium fluoride in augmenting trabecular bone mass in women over the age of 65 years while preserving cortical bone. Subjects will be randomized into two groups. Patients in Group A will receive slow release sodium fluoride and calcium citrate. Patients in Group B will receive placebo and calcium citrate. Important outcome measures include bone density, fracture rate, functional status, and adverse effects. Additional areas of investigation include the characterization and treatment of osteoporosis in Werner's Syndrome and the pathophysiology of osteoporosis in the elderly. Teaching objectives include the continued development of an academic nursing home for medical student and resident training. Ultimately, the candidate will help develop and institute a geriatrics curriculum spanning undergraduate and graduate levels. The University, Parkland Memorial Hospital, and the Dallas Home for the Jewish Aged provide clinical settings that reflect a representative population of the elderly, that is, men and women of a wide racial, and socioeconomic background. This environment serves as an ideal setting for teaching and conducting aging research.