CAROTENOIDS, CHOLESTYRAMINE AND CORONARY HEART DISEASE

类胡萝卜素、考来烯胺与冠心病

• 批准号: 2226560
• 负责人: DEXTER L MORRIS
• 金额: $ 3.32万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2226560
• 关键词: antioxidants; atherosclerosis; blood chemistry; carotenoids; chemoprevention; cholestyramine; coronary disorder; heart disorder chemotherapy; human subject; human therapy evaluation; low density lipoprotein; tobacco abuse

Carotenoids have recently been postulated to prevent coronary heart disease (CHD) by the prevention of oxidation of low-density lipoproteins to more atherogenic compounds. The proposed study will test this hypothesis by examining data from the Lipid Research Clinics Coronary Primary Prevention Trial (LRC-CPPT) and Follow-up. This randomized, placebo-controlled trial examined the effectiveness of cholestyramine in reducing CHD among hyperlipidemic men. Baseline serum carotenoid measurements and CHD events/deaths are available for this cohort of over 3700 men with 14 year of follow-up. The relationship between baseline serum carotenoids and subsequent CHD will be examined in the placebo group adjusting for smoking and other important covariates. This relationship will also be studied in the cholestyramine group to assess the interaction between the lipid lowering and carotenoid lowering effects of cholestyramine. The proposed study will add important information concerning the possibility of using carotenoids to prevent CHD.

类胡萝卜素最近被认为可以预防冠心病 通过预防低密度脂蛋白氧化治疗冠心病 更易致动脉粥样硬化的化合物。 拟议的研究将测试这一点 通过检查脂质研究诊所冠状动脉的数据来假设 一级预防试验（LRC-CPPT）和随访。这种随机的， 一项安慰剂对照试验检查了考来烯胺在 减少高血压男性的冠心病。 基线血清类胡萝卜素 测量和CHD事件/死亡可用于该队列， 3700名男性，随访14年。 基线之间的关系 将在安慰剂组中检查血清类胡萝卜素和随后的CHD 调整吸烟和其他重要协变量的组。 这 还将在考来烯胺组中研究相关性，以评估 降脂和降类胡萝卜素的相互作用 考来烯胺的作用 这项研究将增加重要的 关于使用类胡萝卜素预防的可能性的信息 冠心病