AMALGAM-INDUCED CHANGES IN ANTIBIOTIC RESISTANT FLORA

牙科修复材料最重要的影响被考虑。 是那些直接影响人类宿主的生理的东西。 然而，我们最近的实验室研究表明，安装 猴子的汞合金充填物会导致汞和汞的快速增殖 具有抗药性的口腔和肠道细菌。有没有可能 这种由汞合金引起的细菌耐药性增加可能也会发生在 流行病学数据表明，人类有很强的 汞抵抗的发生与多发性心肌梗死的相关性 人类肠道菌群中的抗生素耐药性，即使是那些已知的 而不是最近服用过抗生素。不幸的是，数据 将耐药菌的增殖与汞合金特别相关 个人的地位目前还不清楚。当前的公众 抗生素耐药性日益普遍的健康问题 病原体使得确定例行程序是否 暴露于牙科汞齐产生的汞会刺激 多重抗药性细菌在人类宿主中的增殖。 因此，我们建议量化汞和抗生素耐药性的变化 在个体受试者的牙龈和肠道细菌中 他们第一次接受银汞合金修复体的场合。 我们将检验从我们的动物研究中得出的假设 在幼稚的对象中安装银汞合金填充物(即 从未使用过任何汞合金填充物)，导致罕见的Pre-Pre 现有的汞和抗生素耐药细菌菌株在两个 牙龈和肠道菌群。重要的是要确定人类是否 植物群的反应方式与猴子的植物群相同，因为 人类正常菌群中抗生素耐药性的增加对 牙科银汞合金释放的汞的选择性压力将构成 一种新的和以前未被认识到的风险因素在广泛使用 汞合金牙科修复体。

The most important effects of dental restorative materials are considered to be those which directly impinge on the physiology of the human host. However, our recent laboratory studies have demonstrated that installation of amalgam fillings in monkeys results in a rapid proliferation of Hg and antibiotic resistant oral and intestinal bacteria. The possibility that this amalgam-provoked increase in bacterial resistance might also occur in humans is suggested by epidemiological data indicating a strong correlation between the occurrences of Hg resistance and of multiple antibiotic resistances in the intestinal flora of humans, even those known not to have recently consumed an antibiotic. Unfortunately, data specifically correlating the proliferation of resistant flora to amalgam status of individual humans are presently lacking. The current public health concern with the increasing prevalence of antibiotic resistant pathogens makes it very important to determine whether the routine exposure to Hg arising from dental amalgams can stimulate the proliferation of multiply antibiotic resistant bacteria in the human host. Thus, we propose to quantify the changes in Hg and antibiotic resistances in the gingival and intestinal bacteria of individual human subjects on the occasion of their receiving their first dental amalgam restorations. We will test the hypothesis, arising from our animal studies, that installation of amalgam fillings in a naive subject (i.e. one who has never had any amalgam fillings), leads to a proliferation of rare pre- existing Hg and antibiotic resistant bacterial strains in both the gingival and intestinal flora. It is important to determine whether human flora responds in the same way as the monkey flora because, such an enrichment of antibiotic resistance in human normal flora in response to the selective pressure of Hg released from dental amalgam would constitute a novel and previously unrecognized risk factor in the widespread use of amalgam dental restorations.