PATHOPHYSIOLOGY OF PRESBYACUSIS

老年痴呆的病理生理学

• 批准号: 3732279
• 负责人: RICHARD A SCHMIEDT
• 金额: --
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3732279
• 关键词: aging; auditory reflex; biological models; calcium; chlorine; cochlea; ear hair cell; endolymph; evoked potentials; gerbil /jird; hydrogen; ion transport; noise biological effect; pathology; perilymph; physiology; potassium; presbycusis; sodium

Experiments are proposed to investigate some of the physiological changes that take place in the peripheral auditory system as the result of aging in a quiet environment and aging in an environment of low-level noise. Our major goal is to identify some of the mechanisms in the cochlea that deteriorate with age and chronic noise exposure. Preliminary results suggest that dysfunction in the ion-pumping tissue along the cochlear duct may be responsible for certain types of hearing loss seen with age. Studies are also proposed to examine some effects of age and noise on the second-order neurons in the cochlear nucleus. The purpose of the cochlear nucleus studies is to begin to examine how the central nervous system responds to long-term low-level exposures of noise. The proposed work has direct bearing on human studies concerned with the gradual loss of hearing often found in the elderly, a process termed presbyacusis. Systematic studies in animals under controlled conditions will provide an opportunity to test various hypotheses of how age and environment interact to change the peripheral auditory system.

提出了实验来研究一些 外周听觉发生的生理变化 系统在安静的环境中衰老和衰老 低级噪音的环境。 我们的主要目标是确定 耳蜗中的某些机制随着年龄的增长而恶化 和慢性噪音暴露。 初步结果表明 沿着耳蜗的离子泵组织功能障碍 可能负责某些类型的听力损失 年龄。 还提出了研究以检查年龄的某些影响 和耳蜗核中二阶神经元上的噪声。 耳蜗核研究的目的是开始 检查中枢神经系统如何对长期做出反应 低级噪声暴露。 拟议的工作直接 与人类研究有关的逐渐丧失 听证会经常在老年人中发现，这是一个称为的过程 长老会。 对动物受控的动物的系统研究 条件将为测试各种假设提供机会 年龄和环境如何相互作用以改变周边 听觉系统。