TISSUE CULTURE/GROWTH FACTOR STUDY--METABOLIC DISORDERS

细胞内分泌学/副分泌学/自分泌学是 分离的细胞及其环境的解剖和重建 为了了解生理学对生长、机能的调节作用 和差异化。这一知识适用于特定类型的细胞 组成特定组织对于理解和干预是必不可少的 与特定组织相关的代谢性疾病。本节目 试图了解新陈代谢的基础。疾病的应用 这些细胞水平的原理与现代蛋白质化学、分子 生物和遗传方法该计划由四个部分组成 解决具体问题的相互关联但新颖的项目 关于血管、肝脏的生长、功能和分化， 脂肪和胸腺组织。两个项目考虑详细的分子 关于受体、近端信号的性质的问题 由因子(血管内皮细胞生长因子和 肝素结合成纤维细胞生长因子与受体的相互作用 对产生的信号进行控制。两个项目探索整合 表皮生长因子受体与磷脂酶的相互作用 A2/前列腺素信号通路的体内外研究。这些项目是 以最先进的蛋白质化学和分子核心为后盾 实验室，后者包括拟议建立一个 转基因动物设施。

Cellular endocrinology/paracrinology/autocrinology is the science of dissection and reconstitution of isolated cells and their environment in order to understand the physiology of the regulation of growth, function and differentiation. This knowledge applied to particular cell types that compose particular tissues is essential to understand and intervene in metabolic disease associated with specific tissues. This program seeks to understand the metabolic basis of. disease by application of these cellular level principles with modern protein chemical, molecular biological and genetic approaches The program is composed of four interrelated, but novel, projects which address specific questions concerning growth, function and differentiation of vascular, liver, adipose and thymic tissues. Two projects consider detailed molecular problems concerning the nature of the receptor, the proximal signal generated by factor (vascular endothelial cell growth factor and heparin-binding fibroblast growth factor)-receptor interaction and the control of the resulting signal. Two projects explore the integration of the EGF-receptor kinase interaction with the phospholipase A2/prostaglandin signal pathway in vitro and in vivo. The projects are backed by state-of-the-art protein chemistry and molecular core laboratories, the latter of which includes proposed establishment of a transgenic animal facility.