Engineering an environmentally-friendly metered dose inhaler

设计环保型定量吸入器

• 批准号: DP200102016
• 负责人: Dr Daniel Duke
• 金额: $ 12.99万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-12-19 至 2023-12-19
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102016
• 关键词: Engineering; environmentally; friendly; metered; dose

This project aims to deliver a novel simulation framework to accurately predict the behaviour of metered dose inhaler sprays using advanced numerical methods for flash-evaporating turbulent flows developed by the investigators. The project expects to generate new knowledge of the complex physics which occur in these devices through a first of its kind combination of unsteady non-equilibrium thermodynamics, turbulence and spray models. Expected outcomes of this project include a novel ability to predict and optimise the performance of inhalers to suit environmentally-friendly replacement propellants. This will significantly benefit the pharmaceutical sector as it will accelerate the design of next-generation inhalers and propellants.

该项目旨在提供一种新的模拟框架，利用研究人员开发的闪蒸湍流的先进数值方法，准确预测计量吸入器喷雾的行为。该项目希望通过非定常非平衡热力学、湍流和喷雾模型的首次组合，产生关于这些设备中发生的复杂物理的新知识。该项目的预期成果包括预测和优化吸入器性能以适应环境友好型替代推进剂的新能力。这将大大有利于制药部门，因为它将加快下一代吸入器和推进剂的设计。