A novel integrating probe for whole tablet Raman Spectrometry

制药业是英国附加值最高的行业。片剂生产中的两个关键问题是假冒产品和缺乏整片测量。本可行性研究将探讨一种可能的解决方案，即通过使用一种新的和创新的采样探头，将标准COTS光谱仪制成一个完整的片剂采样装置。拉曼光谱法被用作QC技术，但目前只有非常昂贵的系统才能对非常小的目标区域进行采样。所提出的探针将均匀混合，然后捕获从整个6 mm平板电脑发出的光，从而使用相对便宜的COTS光谱仪对整个平板电脑进行批量测量，并提供低于4万英镑的完整解决方案。它可能被制造得足够坚固，以便在许多领域进行实地部署，例如用于非法药物识别的法医和执法。

The Pharmaceutical industry is the UK’s highest added-value industry. Two key problems in the production of pharmaceutical tablets are counterfeit products and the lack of whole tablet measurements. This feasibility study will investigate a possible solution whereby a standard COTS spectrometer can be made into a whole tablet sampling device by using a new and innovative sampling probe. Raman spectrometry is used as a QC technique but currently only very expensive systems can sample more than very small target areas. The proposed probe will uniformly mix then capture the light emitted from an entire 6mm tablet, enabling bulk measurement of a whole tablet using a relatively cheap COTS spectrometer and providing a complete solution for under £40k. It could potentially be made rugged enough for field deployment in many areas, such as forensic and law enforcement for illegal drug identification.