Quiescent Microbial Cell Factories

静止微生物细胞工厂

• 批准号: 132126
• 金额: $ 13.38万
• 依托单位: CENTRE FOR PROCESS INNOVATION LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=132126
• 关键词: Quiescent; Microbial; Cell; Factories

Many of the chemicals used to manufacture plastics, fuels and commodities are produced frommicroorganisms grown on various feedstocks in fermenters. This project will progress innovativepatented technology which suspends unnecessary cell metabolism and growth while still enablingenhanced production of chemical products, a state known as quiescence. The advantages of quiescentcell technology (Q-Cells) are enabled for bioreactors operating under optimal production conditionswith concomitant improved productivity, efficient and cost effective use of the feedstock and reducedwaste generation. The mechanism to improve control of quiescence will be investigated within theconstraints of industrial fermentation conditions under scale-down. This study will assess the genericapplicability of the technology to improve competitiveness of Industial Biotechnology to produce bulkchemicals.

许多用于制造塑料、燃料和日用品的化学品都是由发酵罐中各种原料上生长的微生物生产的。该项目将推进创新的专利技术，暂停不必要的细胞代谢和生长，同时仍然能够提高化学产品的生产，这种状态被称为静止状态。静态池技术（Q-Cells）的优势在于能够使生物反应器在最佳生产条件下运行，同时提高生产率，有效和成本效益地使用原料并减少废物产生。将在工业发酵条件的限制下研究改善静止控制的机制。本研究将评估该技术的一般适用性，以提高工业生物技术生产大宗化学品的竞争力。