Quiescent Microbial Cell Factories

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Many of the chemicals used to manufacture plastics, fuels and commodities are produced frommicroorganisms grown on various feedstocks in fermenters. This project will progress innovativepatented technology which suspends unnecessary cell metabolism and growth while still enablingenhanced production of chemical products, a state known as quiescence. The advantages of quiescentcell technology (Q-Cells) are enabled for bioreactors operating under optimal production conditionswith concomitant improved productivity, efficient and cost effective use of the feedstock and reducedwaste generation. The mechanism to improve control of quiescence will be investigated within theconstraints of industrial fermentation conditions under scale-down. This study will assess the genericapplicability of the technology to improve competitiveness of Industial Biotechnology to produce bulkchemicals.