Digital Holographic Microscopy for Morphology-based Enrichment of Circulating Tumour Cells

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In the UK, cancer is the second most common cause of death and is the cause of death that is most costly to the economy. Over 90% of deaths follow metastasis, where secondary tumours are established in the body. Unfortunately, symptoms are usually experienced after metastasis, by which time treatments are often ineffective.We have designed a technology to identify and enrich ultra-rare tumour cells from a blood sample, before secondary tumours are established. This will enable earlier and better-informed clinical decisions, and research into more effective treatments. Our novel design is distributable and affordable such that the benefits will be accessible to a large proportion of society.