PHYSIOLOGICAL MEASURES OF DYSLEXIA

在这个资助项目的头五年里，生理学研究 使用局部脑血流量、事件相关电位和正电子 发射断层扫描分别显示了神经的改变 阅读障碍患者的组织结构，尤其是左半球 个人。目前的提案旨在统一企业资源规划和企业资源规划 生理方法以及核磁共振图像整合成一个 神经行为底物的解剖学和行为学描述 阅读困难症。相应地，生理测量将在 选择认知任务以引发特定的、本地化的任务 激活的区域。在三组受试者(阅读障碍者和正常人)中 读者)有了记录良好的儿童阅读数据，将有四项任务 通过这些方法进行测量。在实验1中，一组10人将 在正电子发射计算机断层扫描过程中执行两项听觉语言激活任务。在……里面 实验二，由40人组成的小组进行跨通道语言激活 同时进行正电子发射计算机断层扫描和事件相关电位测量的任务。所有PET上的MR图像 扫描参与者将允许重建和测量 颞叶扁平和尾状核以确定解剖特征 诵读困难症。在实验3中，另一组40人将进行视觉测试 字母和单词辨别范例，同样是在同时的ERP期间 PET测量，结合MR图像进行解剖重建。在……里面 实验4,100名阅读障碍不同的受试者，他们的配偶， 他们的150个孩子将接受事件相关电位测量 在各种可视任务期间，允许直接与其父级进行比较 数据以及儿童时期的纵向正常、阅读障碍、 以及在我们目前的头五年收集的风险样本 计划项目。我们将专门测试一个么正的假设， 潜在的生理缺陷表现在这些生理缺陷中的每一个 测量域。

In the first five years of this funded project, physiological studies using regional cerebral blood flow, event-related potentials, and positron emission tomography have separately suggested alterations of neural organization, particularly in the left hemisphere, in dyslexic individuals. The current proposal aims to unify the ERP and PET physiological methods as well as MRI profiles into an integrated anatomical and behavioral description of the neurobehavioral substrate of dyslexia. Accordingly, physiological measurements would be made during the performance of cognitive tasks chosen to elicit specific, localized regions of activation. In three groups of subjects (dyslexics and normal readers) with well-documented childhood reading data, four tasks will be measured across these methods. In Experiment 1, a group of 10 will perform two auditory linguistic activation tasks during PET scanning. In Experiment 2, a group of 40 will perform crossmodal linguistic activation tasks during simultaneouS PET and ERP measurement. MR images on all PET scan participants will allow reconstruction and measurement of the temporal plana and caudates to determine the anatomical characterization of dyslexia. In Experiment 3, another group of 40 will perform visual letter and word discrimination paradigms, again during simultaneouS ERP and PET measurement, with MR images for anatomical reconstruction. In Experiment 4, 100 subjects varying in reading disability, their spouses, and 150 of their children will undergo event-related potential measurement during various visual tasks, allowing direct comparison to their parent data as well as to the childhood longitudinal normal, reading impaired, and at-risk samples collected in the first five years of our current program project. We will specifically test the hypothesis of a unitary, underlying physiological deficit manifest in each of these physiological measurement domains.