EXTALcoat : External Lubrication Coating Inspection System by Dynamic Laser Speckle Imaging

EXTALcoat：动态激光散斑成像外部润滑涂层检测系统

• 批准号: 132872
• 金额: $ 14.66万
• 依托单位: GASFILL LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=132872
• 关键词: EXTALcoat; External; Lubrication; Coating; Inspection

Tablets are still the majority form of dosage, used by billions of people worldwide to deliver-life changing remedies. Tablet production techniques have barely changed over the last 100 years, until recently with the advent of new formulations (e.g. fast dissolving tablets that dissolved in the mouth without water) coupled to more efficient continuous process technologies with fewer process steps. The development of these new systems however has not been matched by the quality control systems that ensure product safety and efficacy. This project is proposing a new way of analysing the product during the manufacturing process to ensure that each and every tablet is produced to the same specification. The new instrument being proposed is based on the use of a laser which gives a speckled image of the tablet surface from which it is possible to determine certain quality attributes of the tablet, such as hardness and coating thickness, while providing opportunities for feedback control of the production process itself.

片剂仍然是主要的剂量形式，全球数十亿人使用片剂来提供改变生活的药物。在过去的100年里，片剂生产技术几乎没有变化，直到最近出现了新的配方（例如，快速溶解的片剂，无需水即可在口中溶解），加上更有效的连续工艺技术，工艺步骤更少。然而，这些新系统的开发并没有与确保产品安全性和有效性的质量控制系统相匹配。该项目提出了一种在生产过程中分析产品的新方法，以确保每一片都按照相同的规格生产。所提出的新仪器是基于使用激光器，该激光器给出片剂表面的斑点图像，由此可以确定片剂的某些质量属性，例如硬度和涂层厚度，同时为生产过程本身的反馈控制提供机会。