MEASURING TEWL AND SKIN SURFACE PH IN THE ELDERLY

描述：（改编自研究者摘要） 护理研究是检查经皮水之间的关联 在会阴皮炎的发展中， 并进行一项试点干预研究，以防止会阴 皮炎 本研究将回答以下研究问题：（1） 经表皮水分流失是否有统计学显著差异 和皮肤表面的pH值之间的差异 (2)是 经表皮水分丢失量有统计学显著差异， 尿便失禁老年人与孤立性 失禁？ (3)是否有统计学上的显著差异， 尿便失禁老年人会阴皮炎发生率 与单独失禁（尿失禁或大便失禁）的老年人相比？ (4)有没有 会阴发育率的统计学显著差异 皮炎取决于年龄，性别，时间长度成人一次性内裤 每24小时佩戴次数、失禁发作次数、次数 成人内裤检查和变化，粪便的一致性，和作用的 报告失禁的患者？ (5)用一种 酸性溶液将皮肤的pH值维持在酸性水平（小于pH值 的5.9），从而预防老年人的会阴皮炎？ 两相 将进行前瞻性纵向临床研究。 在第一阶段，双方 a受试者间（控制与失禁）和受试者内设计 （尿失禁、粪便失禁和尿便失禁）。 二百 20名受试者将采用连续系列设计， 城市医疗中心 在220名受试者中，100名将是大陆老年人， 将提供经表皮水分流失和皮肤表面pH值的基线数据 程度. 其余受试者（120例）将出现失禁，并符合 一般入选标准。 会阴评估和各种皮肤 每周进行三次测量。 描述性统计， 计划进行三因素方差分析和考克斯回归分析， 分析这个阶段的数据。 在第二阶段，重复测量加倍 盲法设计将在城市医疗中心进行。 六十 将采用连续系列设计获得失禁受试者。 符合入选标准后，将随机分配每例受试者 控制组和实验组。 实验 组将接受酸性皮肤清洗，而不是水之前， 涂抹保湿霜和防潮剂。 每例受试者将 每周评估五次会阴皮炎的发展。 只 主要研究者将知道哪些受试者正在接受酸性药物， 酸洗 描述性统计和单因素方差分析将 在本研究阶段使用。 这项研究的结果预计将 为研究会阴癌的发病机制和治疗提供了有价值的资料 老年人皮炎。 这项研究还将提供信息， 指导对一个经常被忽视的健康问题进行进一步的干预研究 在乎

DESCRIPTION: (Adapted from investigator's abstract) The purpose of this nursing study is to examine the association between transepidermal water loss (TEWL) and skin surface pH in the development of perineal dermatitis in the elderly and to conduct a pilot intervention study to prevent perineal dermatitis. This study will answer the following research questions: (1) Is there a statistically significant difference in transepidermal water loss and skin surface pH levels between continent and incontinent elders? (2) Is there a statistically significant difference in transepidermal water loss and pH levels in urofecal incontinent elders versus elders with isolated incontinence? (3) Is there a statistically significant difference in the rate of developing perineal dermatitis for urofecal incontinent elders versus elders with isolated incontinence (urinary or fecal)? (4) Is there a statistically significant difference in the rate of developing perineal dermatitis depending on age, gender, length of time adult disposable briefs are worn per 24 hour period, number of incontinent episodes, number of times adult briefs are checked and changes, stool consistency, and role of the patient in reporting incontinence? (5) Does treating the skin with an acidic acid solution maintain the skin's pH at an acidic level (less than pH of 5.9), thus preventing perineal dermatitis in the elderly? A two phase prospective longitudinal clinical study will be conducted. In Phase I, both a between subjects (continent vs incontinent) and within subjects design (urinary, fecal, and urofecal incontinent) will be used. Two hundred and twenty subjects will be obtained using a consecutive series design at an urban medical center. Of the 220 subjects, 100 will be continent elders who will provide baseline data on transepidermal water loss and skin surface pH levels. The remaining subjects (120) will be incontinent and meet the general inclusion criteria. Perineal assessment and various skin measurements will be obtained three times per week. Descriptive statistics, three-way analysis of variance, and Cox regression analysis are planned to analyze the data in this phase. In Phase II a repeated measures double blind design will be conducted at an urban medical center. Sixty incontinent subjects will be obtained using a consecutive series design. After meeting the inclusion criteria, each subject will be randomly assigned to either the control group or the experimental group. The experimental group will receive an acidic acid skin wash rather than water prior to applying a moisturizer and moisture repellant. Each subject will be assessed five times a week for the development of perineal dermatitis. Only the principal investigator will know which subjects are receiving the acidic acid wash. Descriptive statistics and one-way analysis of variance will be used on this phase of the study. Results of this study are expected to provide valuable data on the pathogenesis and treatment of perineal dermatitis in the elderly. This study will also provide information to guide further intervention studies in an often-ignored problem in health care.