POC-ASTHMA: Point of care exhaled breath test for asthma diagnosis

POC-ASTHMA：用于哮喘诊断的护理点呼气测试

• 批准号: 133785
• 金额: $ 15.02万
• 依托单位: APPLIED NANODETECTORS
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=133785
• 关键词: POC; ASTHMA; Point; care; exhaled

"We propose to investigate the feasibility of a point of care (POC) exhaled breath test for the diagnosis of asthma for use in primary care setting. The rapid and accurate diagnosis of asthma and identification of patients would be essential to ensure that adequate treatment, including hospitalisation when necessary, is implemented as early as possible. This type of diagnostic techniques would lead to more efficacious treatments and help to reduce the burden of disease.Asthma is mainly diagnosed principally on the basis of a careful clinical history take taken by a clinician. However, studies of adults diagnosed with asthma suggest that up to 30% do not have clear evidence of asthma. There is a critical need for objective testing using fractional exhaled nitric oxide (FeNO) and detection of volatile organic compounds (VOCs) that would offer a significant improvement to current practise.We will work on innovatively integrating these two new sensor elements into a handheld device for use by healthcare professionals. A low-cost gas sensor fabricated using active nanomaterial metal oxide (MOx) gas sensor array and flexible polymer substrates for the detection FeNO and VOC biomarkers in exhaled breath associated with the diagnosis and management of asthma. A new flow sensor fabricated using new nanomaterial formulations that can detect and measure gas flow that could be used to make lung function measurements.Nanomaterial formulations will be carefully formulated and deposited onto plastic substrates and subsequently modified to selectively detect FeNO and VOC biomarkers. The printed FeNO gas sensor will be then excited using Applied Nanodetectors new patented innovative excitation technique and then exposed to test gases mixtures to optimize the sensor performance. The target is to provide breakthrough technology in diagnostics which can potentially significantly lower measurement costs and improve diagnostic testing. This would lead to a reduction in costly drugs given to people misdiagnosed and also early diagnosis will ensure patients get the appropriate treatment leading to improve outcomes. Exploitation of these project results will lead to development of prototype that can used for clinical validation and clinical utility studies."

“我们建议研究在初级保健机构中使用点护理（POC）呼气试验诊断哮喘的可行性。对哮喘的快速和准确诊断以及对患者的识别对于确保尽早实施适当的治疗，包括必要时的住院治疗至关重要。这种类型的诊断技术将导致更有效的治疗，并有助于减轻疾病负担。哮喘的诊断主要基于临床医生详细的临床病史。然而，对被诊断患有哮喘的成年人的研究表明，多达30%的人没有明确的哮喘证据。迫切需要使用分数呼出一氧化氮（FeNO）和挥发性有机化合物（VOCs）的检测进行客观测试，这将对当前的实践提供重大改进。我们将致力于创新地将这两个新的传感器元件集成到一个手持设备中，供医疗保健专业人员使用。使用活性纳米材料金属氧化物（MOx）气体传感器阵列和柔性聚合物衬底制造的低成本气体传感器，用于检测呼出气体中与哮喘诊断和管理相关的FeNO和VOC生物标志物。一种新型流量传感器，使用新的纳米材料配方制造，可以检测和测量可用于肺功能测量的气体流量。纳米材料配方将被精心配制并沉积在塑料衬底上，随后进行修饰，以选择性地检测FeNO和VOC生物标志物。打印的FeNO气体传感器将使用Applied Nanodetectors的新专利创新激励技术进行激励，然后暴露在测试气体混合物中以优化传感器的性能。目标是提供诊断方面的突破性技术，这可能会显著降低测量成本并改善诊断测试。这将减少给误诊患者的昂贵药物，而且早期诊断将确保患者得到适当的治疗，从而改善结果。利用这些项目结果将导致可用于临床验证和临床效用研究的原型的开发。”