Real-Time Blood Propofol Monitoring

实时血液异丙酚监测

• 批准号: 133875
• 金额: $ 43.05万
• 依托单位: SOMNUS SCIENTIFIC LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=133875
• 关键词: Real; Time; Blood; Propofol; Monitoring

Propofol is an intravenous drug used to induce general anaesthesia (unconsciousness or drug induced sleep). It can also be administered by continuous infusion to keep the patient asleep and has substantial benefits for patients compared with the use of anaesthetic gases. These benefits include a carefully controlled, smooth induction of anaesthesia and a rapid, high quality recovery with a very low incidence of nausea. Propofol has less impact on memory, especially in susceptible patients. Patients who have cancer and are anaesthetised with propofol are more likely to be alive 5 years later than those given gaseous anaesthesia. Emerging laboratory evidence is helping to explain this.There are benefits to the anaesthetist too. Some patients cannot be anaesthetised with a gas whilst equipment or environmental concerns prevent its use in others. The anaesthetist has no worries about the patient awakening during a difficult instrumentation of the airway (during which a gas cannot be delivered).Propofol infusions are also used extensively to sedate patients (make them calm and sleepy but still responsive) such as those in intensive care units.During gaseous anaesthesia the gas can be measured in the patient's breath, this shows that it is being delivered to the patient as well offering a measurement of how much is in their system. During intravenous anaesthesia it would be ideal if the amount of propofol in the blood could be monitored and displayed continuously. Such a 'real-time' monitor does not currently exist. Blood propofol concentrations can be measured by sending samples to a laboratory but the delay means that this does not meet the anaesthetist's need for immediate and continuous information.A real-time blood propofol monitor would increase patient safety by:* Providing evidence that the drug is being delivered to the patient (and thus a rapid indication of an accidentally disconnected infusion line).* Indicating how deeply the patient is anaesthetized or sedated* Refining the dosing calculations built into anaesthetic infusion pumps* Moving toward personalised anaesthesia by adjusting drug doses to individual patientsThis application is being made to support the development of a functioning prototype real-time blood propofol measuring system that works in a laboratory. Required milestones include the invention of a sensor that detects propofol at clinically relevant concentrations, integrating it into a recovery system for use in blood, and linking it to a data display. Further work will be required to produce a clinically useful monitor.

异丙酚是一种静脉注射药物，用于诱导全身麻醉(无意识或药物诱导的睡眠)。它也可以通过持续输液来使患者保持睡眠，与使用麻醉气体相比，它对患者有实质性的好处。这些好处包括精心控制、平稳的麻醉诱导和快速、高质量的恢复以及非常低的恶心发生率。异丙酚对记忆的影响较小，特别是对易感患者。癌症患者使用异丙酚麻醉后，比气态麻醉者更有可能在5年后存活。新出现的实验室证据帮助解释了这一点。这对麻醉师也有好处。一些患者不能用气体麻醉，而设备或环境方面的考虑阻止了其他患者的使用。麻醉师不担心病人在困难的呼吸道检查中醒来(在此期间无法输送气体)。异丙酚输液也被广泛用于镇静病人(使他们平静、昏昏欲睡，但仍有反应)，例如在重症监护病房的病人。在气态麻醉期间，可以在病人的呼吸中测量气体，这表明它正在被输送到病人体内，并提供了一个测量他们体内有多少气体的方法。在静脉麻醉期间，如果能连续监测和显示异丙酚在血液中的量，那将是最理想的。这样的“实时”监控器目前还不存在。可以通过将样本送到实验室来测量异丙酚的血药浓度，但延迟意味着这不能满足麻醉师对即时和连续信息的需求。异丙酚实时血药浓度监测仪将通过以下方式提高患者的安全性：*提供药物正在输送给患者的证据(从而快速指示意外断开的输液管道)。*指示患者被麻醉或镇静的程度*改进麻醉剂输注泵内置的剂量计算*通过调整患者的药物剂量走向个性化麻醉这一应用是为了支持在实验室工作的正常运行的异丙酚实时血液测量系统的开发。所需的里程碑包括发明一种传感器，可以检测到临床相关浓度的异丙酚，将其集成到用于血液的回收系统中，并将其连接到数据显示器。还需要进一步的工作才能生产出临床上有用的监护仪。