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MOLECULAR BASIS OF NORMAL AND MUTANT LIMB DEVELOPMENT

MOLECULAR BASIS OF NORMAL AND MUTANT LIMB DEVELOPMENT
正常和突变肢体发育的分子基础
批准号：
2198406
负责人：
PAUL F GOETINCK
金额：
$35.59万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
项目状态：
已结题
起止时间：
1986-01-01 至 1996-02-29
来源：
https://reporter.nih.gov/project-details/2198406
关键词：
cartilage development cartilage disorder cartilage metabolism cell differentiation chick embryo chondrocytes collagen congenital skeletal disorder developmental genetics embryo /fetus extracellular matrix gene expression genetic regulatory element histogenesis hyaluronate laboratory mouse laboratory rabbit limbs mesoderm molecular cloning monoclonal antibody nucleic acid probes nucleic acid sequence posttranslational modifications protein sequence protein structure function proteoglycan site directed mutagenesis tissue /cell culture

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中文摘要
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英文摘要
The overall goal of the research is to understand the developmental processes that take place in Chip embryonic limb. In this developmental system, changes occur in the activity of a number of genes at the time of differentiation of limb mesodermal cells into chondrocytes. We will study: a) the structure-function relationship of the translation products of newly activated genes in the establishment of the cartilaginous matrix, b) the regulatory sequences that are specific for the expression of one of these genes in chondrocytes and c) the morphogenetic consequences of induced and spontaneous mutations that affect cartilage matrix macromolecules.
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SYNDECAN-4 SIGNALING IN CELL-MATRIX INTERACTIONS
  • 批准号：
    6521167
  • 项目类别：
  • 资助金额：
    $32.67万
  • 财政年份：
    1999
  • 负责人：
    PAUL F GOETINCK
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
SYNDECAN-4 SIGNALING IN CELL-MATRIX INTERACTIONS
  • 批准号：
    6636983
  • 项目类别：
  • 资助金额：
    $33.54万
  • 财政年份：
    1999
  • 负责人：
    PAUL F GOETINCK
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
Syndecan-4 signaling in cell-matrix interactions
  • 批准号：
    6877793
  • 项目类别：
  • 资助金额：
    $36.07万
  • 财政年份：
    1999
  • 负责人：
    PAUL F GOETINCK
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
Syndecan-4 signaling in cell-matrix interactions
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