JEFFERSON INTERACTIVE ASTHMA CLINICAL RESEARCH GROUP
杰斐逊互动哮喘临床研究小组
基本信息
- 批准号:2228759
- 负责人:
- 金额:$ 55.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1993
- 资助国家:美国
- 起止时间:1993-09-30 至 1998-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This seeks to establish an interactive asthma clinical research group at
Thomas Jefferson University. The overall goal of participating as part
of a collaborative, multi-centered network is to explore novel approaches
to the treatment of asthma and to create avenues for disseminating
information gained from this research. The Jefferson Clinical Research
Group would be based on existing comprehensive and multi-disciplinary
research and clinical programs in asthma. Two protocols are proposed to
evaluate novel approaches to the treatment of asthma. The first protocol
examines the effects of colchicine in the long-term management of severe,
steroid-dependent asthma. This is a double-blind, randomized, two-year
study using numbers of hospitalizations, doctors' visits, and steroid
requirements as primary efficacy measures. The second protocol is
designed to define the anti-inflammatory potential of a leukotriene-D4
receptor antagonist and a 5-Lipoxygenase inhibitor and to determine
whether either compound can serve as a corticosteroid substitute. For
this study, the inflammatory component of asthma is defined as that
component which is unresponsive to bronchodilator therapy, but responsive
to steroid therapy. This is a double-blind, randomized fourteen-week
study using pulmonary function, symptoms, and other drug use as primary
outcome measures. A further aim of this proposal is to develop a patient
stratification scheme based on clinical, demographic, and laboratory data
with the goal of identifying subgroups of asthmatics who are most likely
to benefit from a specific intervention and also to gain information
regarding disease pathogenesis. The basic premise of this application
is that asthma is not a single nosologic entity; rather, it is a syndrome
comprising multiple disorders having common clinical manifestations but
their own distinct pathogenetic mechanisms. Studies attempting to
discern these differences are critical not only to achieve a better
understanding of asthma, but also to enhance our ability to recognize the
benefits of newer and more specific antiasthmatic agents.
该项目旨在建立一个互动式哮喘临床研究小组
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('James E Fish', 18)}}的其他基金
JEFFERSON INTERACTIVE ASTHMA CLINICAL RESEARCH GROUP
杰斐逊互动哮喘临床研究小组
- 批准号:
2228760 - 财政年份:1993
- 资助金额:
$ 55.13万 - 项目类别:
JEFFERSON INTERACTIVE ASTHMA CLINICAL RESEARCH GROUP
杰斐逊互动哮喘临床研究小组
- 批准号:
3560416 - 财政年份:1993
- 资助金额:
$ 55.13万 - 项目类别:
JEFFERSON INTERACTIVE ASTHMA CLINICAL RESEARCH GROUP
杰斐逊互动哮喘临床研究小组
- 批准号:
2519410 - 财政年份:1993
- 资助金额:
$ 55.13万 - 项目类别:
JEFFERSON INTERACTIVE ASTHMA CLINICAL RESEARCH GROUP
杰斐逊互动哮喘临床研究小组
- 批准号:
2228761 - 财政年份:1993
- 资助金额:
$ 55.13万 - 项目类别:
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