DEVELOPMENT OF STEROID-INDUCED SEXUAL BEHAVIOR

类固醇引起的性行为的发展

• 批准号: 2201217
• 负责人: Deborah H Olster
• 金额: $ 12.12万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA BARBARA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-01 至 1997-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2201217
• 关键词: animal developmental psychology; animal puberty; behavior test; developmental neurobiology; endorphins; estradiol; estrogen receptors; guinea pigs; hormone regulation /control mechanism; hypothalamus; ibotenate; juvenile animal; mature animal; neuroanatomy; norepinephrine; opioid receptor; ovariectomy; preoptic areas; progesterone; progesterone receptors; psychopharmacology; psychophysiology; reproductive development; sex behavior; substance P

Unlike other rodents, juvenile female guinea pigs rarely display sexual receptivity (lordosis) following a variety of estradiol and progesterone treatments that elicit estrous behavior in adult females. The long-range goals of the experiments described in this application are to elucidate the neural mechanisms underlying the behavioral hyporesponsiveness to steroid hormones in immature females. The primary foci of this proposal are a caudally-projecting, steroid responsive pathway originating in the hypothalamus that appears to mediate the behavioral actions of estradiol and progesterone, the neurotransmitters acting within this pathway, and the activity of other central nervous system components, particularly one originating in or traversing the medial preoptic area, that may inhibit or override its activity, during the juvenile period. A combination of physiological, pharmacological and neuroanatomical techniques will be used to determine the integrity, in juvenile females, of the putative pathways mediating steroid-induced lordosis. Several neurotransmitter systems will be studied, to ascertain whether hypoactivity in neurotransmitter systems thought to be stimulatory for lordosis (norepinephrine, substance P) or hyperactivity of systems thought to inhibit receptivity (endogenous opiates) might underlie the juvenile female's immature behavioral response to steroid hormones. The results of these studies will provide insight into the mechanisms of steroid hormone action in the central nervous system, especially within the context of puberty. These data will help establish a framework within which one can study normal, as well as aberrant sexual maturation and/or responsiveness to estradiol and progesterone in humans and laboratory animals.

与其他啮齿动物不同，幼年雌性豚鼠很少表现出性行为 多种雌二醇和孕酮引起的感受性(前凸) 诱导成年雌性发情行为的治疗。长距离的 本申请中描述的实验的目标是阐明 行为低反应性的神经机制 未成熟女性体内的类固醇激素。这项提案的主要焦点是 是一种尾部投射的类固醇反应通路，起源于 下丘脑，似乎参与了雌二醇的行为活动 和黄体酮，作用于这一途径的神经递质，以及 中枢神经系统其他组成部分的活动，尤指 起源于或横穿内侧视前区，可能抑制或 在青少年时期，超越它的活动。一种组合 将使用生理学、药理学和神经解剖学技术 以确定幼年女性的假定通路的完整性 调节类固醇诱导的前凸。几个神经递质系统将 进行研究，以确定神经递质系统是否活动不足 被认为是刺激前凸(去甲肾上腺素，P物质)或 被认为抑制感受性(内源性)的系统过度活跃 阿片剂)可能是幼年雌性的不成熟行为反应的基础 类固醇激素。这些研究的结果将提供洞察力 类固醇激素在中枢神经系统中的作用机制 系统，特别是在青春期的背景下。这些数据将会有所帮助 建立一个框架，在这个框架内，人们可以学习正常，也可以 异常的性成熟和/或对雌二醇和 人类和实验动物体内的黄体酮。