Functional insights into the roles of enteric glia

对肠神经胶质细胞作用的功能性见解

• 批准号: DE200100825
• 负责人: Dr Simona Carbone
• 金额: $ 29.69万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-05-04 至 2024-10-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE200100825
• 关键词: Functional; insights; into; roles; enteric

This project aims to review our current definition of enteric glia populations, and our understanding of their communication mechanisms in the mouse and primate colon. It will generate new knowledge of enteric glia biology using advanced microscopy and image analysis. Calcium imaging and novel biosensors will measure cell signalling in enteric glia. It will provide the most comprehensive analysis of glia connectivity, morphology and receptor expression in the primate colon. Expected outcomes include a detailed map of enteric glia and definitions of their basic biology. This project builds on the techniques and collaborations made by the candidate over recent years. This will benefit our basic understanding of enteric glia biology.

本项目旨在回顾我们目前对肠道胶质细胞群体的定义，以及我们对小鼠和灵长类动物结肠中它们的交流机制的理解。它将使用先进的显微镜和图像分析产生肠胶质细胞生物学的新知识。钙成像和新型生物传感器将测量肠胶质细胞信号。它将提供灵长类动物结肠中神经胶质连通性、形态和受体表达的最全面分析。预期的结果包括肠胶质细胞的详细图谱和它们的基本生物学定义。该项目建立在候选人近年来的技术和合作基础上。这将有利于我们对肠胶质细胞生物学的基本理解。