PIEZOELECTRIC IMMUNOSENSOR FOR DIAGNOSIS OF TB
PIEZOELECTRIC IMMUNOSENSOR FOR DIAGNOSIS OF TB
批准号:
2070921
负责人:
STEVEN C PERLAKY
金额:
$7.12万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1994
资助国家:
美国
项目状态:
已结题
起止时间:
1994-01-01 至 1994-12-31
中文摘要
提出的研究的长期目标是发展一种快速的
英文摘要
The long-term objective of the proposed research is to develop a rapid
method for the diagnosis of tuberculosis. A piezoelectric biosensor
employing antibodies to soluble mycobacterial antigens will be used to
detect these specific antigens and/or whole mycobacteria. Detection of
mycobacterial antigens in a liquid phase will allow the diagnosis of
mycobacterial infection in biological fluids such as sputum,
bronchoalveolar lavage fluid, cerebral spinal fluid and synovial fluid.
Ultimately, gas or vapor phase detection of mycobacterial antigens by a
piezo-immunosensor would allow rapid diagnosis of pulmonary tuberculosis
by detection of mycobacterial antigens in expired human breath.
The feasibility of this novel approach to the diagnosis of tuberculosis
will be tested using monoclonal and polyclonal antibodies to specific
mycobacterial antigens. The antibodies will be coupled to gold
electrodes on AT-cut 9 MHzquartz crystals. The resulting piezoelectric-
immunosensor will be tested for its ability to detect mycobacterial
antigens in culture supernatants and in solutions of antigen vaporized
by a nebulizer.
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会议论文
BONE MARROW BIOPSY AND ASPIRATION DEVICE
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批准号:2104334
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项目类别:
-
资助金额:$6.26万
-
财政年份:1994
-
负责人:STEVEN C PERLAKY
-
依托单位:
PIEZOELECTRIC IMMUNOSENSOR FOR THE DIAGNOSIS OF T B
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批准号:2004054
-
项目类别:
-
资助金额:$36.38万
-
财政年份:1994
-
负责人:STEVEN C PERLAKY
-
依托单位:
PIEZOELECTRIC IMMUNOSENSOR FOR THE DIAGNOSIS OF T B
-
批准号:2070922
-
项目类别:
-
资助金额:$36.61万
-
财政年份:1994
-
负责人:STEVEN C PERLAKY
-
依托单位: