MATCHING PATIENTS TO ALCOHOLISM TREATMENTS--HOUSTON CRU

使患者接受酒精治疗 - 休斯顿 CRU

• 批准号: 2044500
• 负责人: CARLO C. DI CLEMENTE
• 金额: $ 20.62万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE COUNTY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-30 至 1997-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2044500
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse therapy; clinical trials; cognitive behavior therapy; cooperative study; health care service utilization; human data; human subject; human therapy evaluation; information dissemination; interview; longitudinal human study; mental health counseling; motivation; outpatient care; prognosis; psychometrics; psychotherapy; statistics /biometry; substance abuse related disorder

The overall aim of study is to test the "matching hypothesis" that alcohol treatment effectiveness can be increased by assigning clients with certain characteristics to particular treatments. The present application proposes to continue work initiated and conducted over the past five years. The specific aims of study are: to test primary and secondary a priori matching hypotheses over the course of 15 months of follow-up; to conduct psychometric and other analyses of patient, treatment process, and outcome variables to test these matching hypotheses; to examine alternative analytic strategies and variables for testing matching; and to determine the extent to which matching effects persist over a three year period following treatment completion. Data sets collected from the Project MATCH outpatient (N=954) and aftercare (N=774) randomized clinical trial studies will be analyzed to achieve these aims. Clients randomly assigned to one of three treatments, Twelve Step, Cognitive Behavioral, or Motivational Enhancement, have been assessed prior to treatment on baseline and matching variables and followed, at 3 month intervals, for 15 months from treatment assignment to measure their alcohol consumption and other dimensions of outcome. To test longer term matching effects clients in the outpatient arm of the study will be contacted and assessed at 39 months after treatment initiation. In year 08 these data will be analyzed to address this question. It is anticipated that study results will impact on alcohol treatment research and delivery for the next decade. The Project MATCH Steering Committee, following discussion with NIAAA Staff, has chosen to submit a generic proposal across each of the CRUs, reflecting the common protocol and cooperative process that has guided the project across its first five years of operation. However, each CRU has provided site-specific information in the budget, budget justifications, listing of key personnel, consultant/consortium agreements, and human subjects sections of their respective proposals.

这项研究的总体目的是检验“匹配假设”，即酒精 治疗效果可以通过为客户分配某些 特殊的治疗方法。本申请提出 继续开展过去五年开展的工作。的 研究的具体目的是：测试小学和中学的先验 在15个月的随访过程中匹配假设;进行 对患者、治疗过程和结果进行心理测量和其他分析 变量来测试这些匹配的假设;检查替代 用于测试匹配的分析策略和变量;并确定 匹配效应持续三年的程度 治疗完成后。 从项目MATCH门诊患者（N=954）和 将分析术后护理（N=774）随机临床试验研究， 实现这些目标。客户被随机分配到三种治疗中的一种， 十二步，认知行为，或动机增强，已经被 治疗前评估基线和匹配变量， 从治疗分配到治疗结束，每隔3个月随访15个月， 测量他们的酒精消费量和其他方面的结果。测试 长期匹配的影响客户在门诊手臂的研究 将在治疗开始后39个月联系并评估。在 2008年将对这些数据进行分析，以解决这一问题。 预计研究结果将影响酒精治疗 未来十年的研究和交付。 项目匹配指导委员会，在与NIAAA讨论后 工作人员选择在每个CRU中提交一份通用提案， 反映了共同议定书和合作进程， 项目在其运营的前五年。但是，每个CRU都有 在预算、预算理由、 关键人员、顾问/联合体协议和人力资源清单 他们各自提案的主题部分。