MATCHING PATIENTS TO ALCOHOLISM TREATMENTS--HOUSTON CRU

这项研究的总体目标是检验酒精的“匹配假设” 治疗效果可以通过分配某些特定的客户来提高 从特征到特定的治疗方法。本申请提出了 继续开展过去五年启动和开展的工作。这个 研究的具体目标是：检验主要和次要的先验 在15个月的跟踪过程中与假设相匹配的；进行 心理测量学和其他对患者、治疗过程和结果的分析 检验这些匹配假设的变量；检验替代方案 用于测试匹配的分析策略和变量；并确定 匹配效应在三年内持续的程度 在治疗完成后。 从项目匹配门诊(N=954)收集的数据集和 善后(N=774)随机临床试验研究将被分析以 实现这些目标。患者被随机分配到三种治疗方法中的一种， 十二个步骤，认知行为，或动机增强，已经 在治疗前对基线和匹配变量进行评估 每隔3个月随访15个月，从治疗分配到 测量他们的饮酒量和其他方面的结果。为了测试 长期配对影响了研究中门诊部门的客户 将在治疗开始后39个月联系和评估。在……里面 08年将对这些数据进行分析，以解决这个问题。 预计研究结果将对酒精治疗产生影响 未来十年的研究和交付。 项目比赛指导委员会，在与NIAAA讨论后 工作人员已选择提交跨每个CRU的通用提案， 反映共同议定书和合作进程指导了 该项目在其运营的头五年进行。但是，每个CRU都有 在预算中提供具体地点的信息、预算理由、 关键人员、顾问/联合体协议和人力资源清单 以各自提案的各部分为主题。

The overall aim of study is to test the "matching hypothesis" that alcohol treatment effectiveness can be increased by assigning clients with certain characteristics to particular treatments. The present application proposes to continue work initiated and conducted over the past five years. The specific aims of study are: to test primary and secondary a priori matching hypotheses over the course of 15 months of follow-up; to conduct psychometric and other analyses of patient, treatment process, and outcome variables to test these matching hypotheses; to examine alternative analytic strategies and variables for testing matching; and to determine the extent to which matching effects persist over a three year period following treatment completion. Data sets collected from the Project MATCH outpatient (N=954) and aftercare (N=774) randomized clinical trial studies will be analyzed to achieve these aims. Clients randomly assigned to one of three treatments, Twelve Step, Cognitive Behavioral, or Motivational Enhancement, have been assessed prior to treatment on baseline and matching variables and followed, at 3 month intervals, for 15 months from treatment assignment to measure their alcohol consumption and other dimensions of outcome. To test longer term matching effects clients in the outpatient arm of the study will be contacted and assessed at 39 months after treatment initiation. In year 08 these data will be analyzed to address this question. It is anticipated that study results will impact on alcohol treatment research and delivery for the next decade. The Project MATCH Steering Committee, following discussion with NIAAA Staff, has chosen to submit a generic proposal across each of the CRUs, reflecting the common protocol and cooperative process that has guided the project across its first five years of operation. However, each CRU has provided site-specific information in the budget, budget justifications, listing of key personnel, consultant/consortium agreements, and human subjects sections of their respective proposals.