HOMEMADE CEREAL-BASED ORAL REHYDRATION THERAPY

自制谷物口服补液疗法

• 批准号: 2236772
• 负责人: Alan Meyers
• 金额: $ 18.49万
• 依托单位: BOSTON HEALTH AND HOSPITALS DEPARTMENT
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 1996-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2236772
• 关键词: HOMEMADE; CEREAL; BASED; ORAL; REHYDRATION

Diarrhea with dehydration is a common illness among young children in the United States, accounting for over 10% of hospitalizations and 500 deaths per year among children under age five years. Diarrheal dehydration is preventable and treatable with the early and appropriate use of oral rehydration therapy (ORT), the administration of a balanced solution of glucose or stanch and electrolytes. Commercial oral rehydration solutions (ORS) are frequently recommended by health professionals and are widely available in pharmacies and some grocery stores. However, their high cost may serve as an economic barrier to their use by poor families, whose children are most likely to suffer fatal diarrheal dehydration. This proposal addresses this problem by evaluating the safety and effectiveness of homemade cereal--based ORS (C-ORS) in a controlled experimental fashion. C-ORS can be prepared from ingredients commonly found in the home, more safely than sugar-based ORS, and offers the additional advantage of reducing the volume, frequency, and duration of diarrhea. Currently there are no data available on the safety and effectiveness of homemade C-ORS in the U.S. This study will recruit children aged 4-36 months presenting in the Pediatric Emergency Department or Pediatric Primary Care Clinic of Boston City Hospital and Children's Hospital, Boston, with acute diarrhea. Patients will be randomly assigned to one of three treatment groups: Pedialyte, homemade C--ORS, or C-ORS prepared from a packet containing pre-measured cereal and electrolytes. Patients will be followed and data collected by study nurses who will visit the home daily until the illness resolves. Treatment failures, duration and frequency of diarrhea- serum electrolytes, and weight gain will constitute the main outcome variables. Samples of homemade C-ORS will also be obtained and assayed for sodium content. If the experimental C-ORS is found to be safe and effective, child health providers may choose it as a low-cost alternative to commercial ORS that, with proper supervision, may be recommended to families who may otherwise find the cost of ORT to be prohibitive.

脱水腹泻是幼儿中的常见疾病 美国，占住院治疗人数的 10% 以上，死亡人数超过 500 人 每年五岁以下儿童。 腹泻脱水是 早期和适当使用口服药物是可以预防和治疗的 补液疗法（ORT），使用平衡溶液 葡萄糖或淀粉和电解质。商业口服补液溶液 (ORS) 经常被健康专业人士推荐并被广泛使用 在药店和一些杂货店有售。 然而，他们的高 成本可能成为贫困家庭使用它们的经济障碍， 他们的孩子最有可能患上致命的腹泻脱水。 该提案通过评估安全性和 自制谷物 ORS (C-ORS) 在受控条件下的有效性 实验时尚。 C-ORS可由常用成分制备 在家中发现，比糖基 ORS 更安全，并提供 减少音量、频率和持续时间的额外优势 腹泻。目前尚无有关安全性和安全性的数据 自制 C-ORS 在美国的有效性 这项研究将招募 4-36 个月大的儿童在儿科急诊室就诊 波士顿市医院的科室或儿科初级保健诊所以及 波士顿儿童医院，患有急性腹泻。 患者将会 随机分配到三个治疗组之一：Pedialyte、自制 C--ORS，或由装有预先计量的谷物的包装袋制备的 C-ORS 和电解质。 将通过研究跟踪患者并收集数据 护士每天都会到家中探望，直到疾病痊愈。 治疗失败、腹泻持续时间和频率 - 血清 电解质和体重增加将构成主要结果变量。 还将获取自制 C-ORS 样品并进行钠含量分析 内容。 如果发现实验性 C-ORS 安全有效， 儿童保健提供者可能会选择它作为一种低成本的替代品 在适当的监督下，可以建议商业 ORS 否则可能会发现 ORT 费用过高的家庭。