MULTIDISCIPLINARY STUDY OF PCBS & PCDFS AT A WASTE SITE

该计划项目的重点是指定超级基金中的污染物 地点位于纽约州马塞纳的通用汽车铸造厂。一共有九个 单个项目和一个强大的分析核心，每个项目都利用 项目，以及与研究生的协调培训计划 流行病学、生物统计学和统计学、环境健康和 毒物学和土木工程和化学工程。这件事的意义 程序是它使用三种方法解决现场的问题 免费赠送服务。我们将获得测量的水平 污染物在地表和大气中的物理迁移及其示踪 地下水、沉积物、土壤和进入食物链的人类 人口。我们将在动物模型中研究其毒性机制。 系统，重点是神经和免疫毒性。最后，我们将研究 补救过程可能是自然发生的，也可能是可以进行的 由厌氧细菌或超临界流体技术产生。人类 这项提案关注的人口包括9000名土著人口 居住在Akwesasne的美国人，他们的传统渔业水域 也被通用汽车铸造厂的物质污染 作为近乎美国铝业和雷诺兹金属公司的网站。我们将确定 在母乳、血液和尿液中存在68种多氯联苯同系物 在这个社区中尽可能多的新妈妈，并在 以确定接触的程度和来源。在人类和人类中 和动物研究，我们将调查正畸的分布- 被取代的多氯联苯，我们之前的结果表明 多氯联苯的中枢神经系统效应(认知电位降低 和行为障碍)，并与二恶英的分布- 类似的物质，其毒性可能是由ah受体介导的。 我们将研究异种生物的相互作用，它们的影响 毒性当量因子的组合，并确定年龄是否在 暴露对毒性有很大影响。该项目的一个主题是 每一种多氯联苯和多氯二苯并呋喃是一种独特的化合物，两者都不同 物理和生物特性。这项研究的总体目标是 确定这些物质如何从现场迁移到人体内 植物和动物，水和土壤，以及什么是生物效应 这些物质以及它们如何被移除和灭活。

This Program Project is focused on the pollutants at a designated Superfund site at the General Motors Foundry in Massena, NY. There are nine individual projects and a strong analytical core which is utilized by each project, as well as a coordinated training program with post-graduate students in epidemiology, biometry and statistics, environmental health and toxicology and civil and chemical engineering. The significance of this program is that it addresses the problems at the site using three complimentary approaches. We will obtain measurement of levels of contamination and tracing of its physical migration through surface and ground waters, sediments, soils and into the food chain to the human population. We will investigate the mechanisms of toxicity in animal model systems, focusing on neuro- and immunotoxicity. Finally, we will study remedial processes which may be occurring naturally or which can be carried out by anaerobic bacteria or supercritical fluid technology. The human population around which this proposal is focused consists of 9,000 Native Americans who inhabit Akwesasne, and whose traditional fishing waters have been contaminated with substances from the General Motor Foundry, as well as the nearly ALCOA and Reynolds Metals sites. We will determine the presence of 68 PCB congeners in breast milk, blood and urine from as many new mothers as possible in this community, and study a subset in detail in order to determine the degree and source of exposure. In both the human and animal studies we will investigate the distribution of ortho- substituted PCBs, which our previous results suggest are responsible for central nervous system effects of PCBs (reduction of cognitive potential and behavioral disturbances), and compare to distribution of the dioxin- like substances, whose toxicity is presumably mediated by the Ah receptor. We will investigate xenobiotic interactions, the effect of their combination on toxicity equivalency factors, and determine if age at exposure significantly influences toxicity. A theme of the project is that each of the PCB and PCDF congeners is a unique compound, varying in both physical and biologic properties. The overall goal of the study is to determine how these substances migrate from the site into man through plants and animals, water and soils, and what are the biologic effects of these substances and how can they be removed and inactivated.