MULTIDISCIPLINARY STUDY OF PCBS & PCDFS AT A WASTE SITE

该计划项目的重点是指定的超级基金的污染物 位于纽约州马塞纳的通用汽车铸造厂。 有九 每个项目都有一个强大的分析核心， 项目，以及与研究生协调的培训计划 流行病学、生物统计学和统计学、环境卫生和 毒理学以及土木和化学工程。 其意义 该计划是，它解决了问题，在网站上使用三个 互补的方法。 我们将测量 污染和追踪其通过地表的物理迁移， 地下沃茨、沉积物、土壤，并进入人类的食物链 人口 我们将在动物模型中研究毒性的机制 系统，重点是神经和免疫毒性。 最后，我们将研究 可能自然发生的或可以进行的补救过程 通过厌氧细菌或超临界流体技术。 人类 该提案所关注的人口包括9，000名原住民 居住在Akwesasne的美国人，他们的传统捕鱼沃茨 也被通用汽车铸造厂的物质污染了 和美国铝业公司和雷诺兹金属公司的地盘一样 康贝特人将以 母乳、血液和尿液中存在68种多氯联苯同系物， 新妈妈尽可能在这个社区，并详细研究了一个子集， 以确定暴露的程度和来源。 无论是在人类 和动物研究，我们将调查邻位的分布- 替代的多氯联苯，我们以前的结果表明，负责 多氯联苯对中枢神经系统的影响（认知能力降低 和行为障碍），并与二恶英的分布进行比较， 类似物质，其毒性可能由Ah受体介导。 我们将研究异生素的相互作用，它们的影响， 结合毒性等效因子，并确定年龄 暴露显著影响毒性。 该项目的一个主题是， 多氯联苯和多氯二苯并呋喃同系物都是一种独特的化合物， 物理和生物特性。 研究的总体目标是 确定这些物质是如何从现场迁移到人体的， 植物和动物，水和土壤，以及它们的生物效应 这些物质以及它们如何被去除和灭活。

This Program Project is focused on the pollutants at a designated Superfund site at the General Motors Foundry in Massena, NY. There are nine individual projects and a strong analytical core which is utilized by each project, as well as a coordinated training program with post-graduate students in epidemiology, biometry and statistics, environmental health and toxicology and civil and chemical engineering. The significance of this program is that it addresses the problems at the site using three complimentary approaches. We will obtain measurement of levels of contamination and tracing of its physical migration through surface and ground waters, sediments, soils and into the food chain to the human population. We will investigate the mechanisms of toxicity in animal model systems, focusing on neuro- and immunotoxicity. Finally, we will study remedial processes which may be occurring naturally or which can be carried out by anaerobic bacteria or supercritical fluid technology. The human population around which this proposal is focused consists of 9,000 Native Americans who inhabit Akwesasne, and whose traditional fishing waters have been contaminated with substances from the General Motor Foundry, as well as the nearly ALCOA and Reynolds Metals sites. We will determine the presence of 68 PCB congeners in breast milk, blood and urine from as many new mothers as possible in this community, and study a subset in detail in order to determine the degree and source of exposure. In both the human and animal studies we will investigate the distribution of ortho- substituted PCBs, which our previous results suggest are responsible for central nervous system effects of PCBs (reduction of cognitive potential and behavioral disturbances), and compare to distribution of the dioxin- like substances, whose toxicity is presumably mediated by the Ah receptor. We will investigate xenobiotic interactions, the effect of their combination on toxicity equivalency factors, and determine if age at exposure significantly influences toxicity. A theme of the project is that each of the PCB and PCDF congeners is a unique compound, varying in both physical and biologic properties. The overall goal of the study is to determine how these substances migrate from the site into man through plants and animals, water and soils, and what are the biologic effects of these substances and how can they be removed and inactivated.