CLINICAL RESEARCH TRAINING IN NICOTINE DISCRIMINATION

拟议的研究调查了个体差异的基础 在大鼠和大鼠中使用药物歧视范式的吸烟行为 人类。在候选人01年和02年的培训期间，不同之处 在尼古丁的辨别性刺激特性中 其特点是饲养的大鼠对毒扁豆碱的敏感性不同。 每只大鼠体内脱敏的能力将由以下因素决定 测试他们检测特定尼古丁训练量的能力 在最初的挑战剂量后的不同时间。泛化和 将进行各种药理制剂的拮抗研究。 候选人将继续积极参与动物实验室的工作。 当她在03，04年继续进行人体临床研究时， 和05。最初的重点将是建立方法论， 人体尼古丁辨别实验。识别线索 用于尼古丁检测和观察个体差异 不同水平的吸烟者的敏感度是额外的研究 目标。未来的实验将观察人类脱敏作用的差异， 并测试药理泛化和拮抗将与 老鼠研究。

The proposed studies investigate the basis for individual differences in smoking behavior using a drug discrimination paradigm in both rats and humans. During years 01 and 02 of the candidate's training, differences in the discriminative stimulus properties of nicotine will be characterized in rats bred for differences in muscarinic sensitivity. Each rat's capability for in-vivo desensitization will be determined by testing their ability to detect a specific nicotine training dose at various times after an initial challenge dose. Generalization and antagonism studies with various pharmacologic agents will be performed. The candidate will continue active involvement with the animal laboratory as she proceeds on to perform clinical research in humans in years 03, 04, and 05. Initially the focus will be to establish the methodology , for nicotine discrimination experimentation in humans. Identifying the cues for nicotine detection and looking at individual differences in sensitivity amongst different levels of smokers are additional research aims. Future experiments to look at differences in human desensitization, and to test pharmacologic generalization and antagonism will parallel the rat studies.