CLINICAL RESEARCH TRAINING IN NICOTINE DISCRIMINATION

拟议的研究调查了个体差异的基础， 吸烟行为使用药物歧视范例在大鼠和 人类 在01年和02年的候选人的培训，差异 尼古丁的辨别刺激特性 在因毒蕈碱敏感性差异而饲养的大鼠中进行表征。 每只大鼠的体内脱敏能力将通过以下方法确定： 测试他们检测特定尼古丁训练剂量的能力， 在初始攻击剂量后的不同时间。 概括和 将进行各种药理学试剂的拮抗作用研究。 候选人将继续积极参与动物实验室的工作 当她在03年，04年， 和05。 最初的重点将是建立方法， 人体尼古丁辨别实验识别线索 用于尼古丁检测， 不同程度的吸烟者之间的敏感性是额外的研究 目标。 未来的实验将着眼于人类脱敏的差异， 为了测试药理学的普遍性和拮抗作用， 大鼠研究。

The proposed studies investigate the basis for individual differences in smoking behavior using a drug discrimination paradigm in both rats and humans. During years 01 and 02 of the candidate's training, differences in the discriminative stimulus properties of nicotine will be characterized in rats bred for differences in muscarinic sensitivity. Each rat's capability for in-vivo desensitization will be determined by testing their ability to detect a specific nicotine training dose at various times after an initial challenge dose. Generalization and antagonism studies with various pharmacologic agents will be performed. The candidate will continue active involvement with the animal laboratory as she proceeds on to perform clinical research in humans in years 03, 04, and 05. Initially the focus will be to establish the methodology , for nicotine discrimination experimentation in humans. Identifying the cues for nicotine detection and looking at individual differences in sensitivity amongst different levels of smokers are additional research aims. Future experiments to look at differences in human desensitization, and to test pharmacologic generalization and antagonism will parallel the rat studies.