SYNTHESIS OF NEW ANTIHIV AGENTS RELATED TO CALANOLIDE A

描述：首席调查员指出，最近 已发现一类非常有效的抗艾滋病毒天然产品 因为甘蓝内酯很难从天然的 消息来源。他报告说，在他的第一阶段工作中，他已经完成了 外消旋甘蓝内酯A的全合成 报告的化合物，使用容易获得的起始材料。他 声明在第二阶段研究计划期间，他计划改进 他的合成方法论，以便准备大量的 Calanolide A以高效和经济的方式，他还 打算设计和合成一些精选的类似物 可能具有更强的抗HIV活性的Calanolide A，副作用更少 效果，以及比亲本天然药物更好的给药性能 产品。

DESCRIPTION: The principal investigator notes that the recently discovered class of remarkably effective anti-HIV natural products known as the calanolides are extremely difficult to obtain from natural sources. He reports that in his Phase I work, he has completed the total synthesis of racemic calanolide A, the most potent of the compounds reported, using readily available starting materials. He states that during the Phase II research program, he plans to improve his synthetic methodology so as to prepare large quantities of calanolide A in an efficient and economical manner, and that he also intends to design and synthesize a number of selected analogs of calanolide A which may possess more potent anti-HIV activity, fewer side effects, and better drug delivery properties than the parent natural product.