EFFECT OF ORTHODONTIC TOOTH MOVEMENT ON PERIODONTIUM

排列不齐的牙齿发挥了重要作用的病因和进展， 牙周病 患者难以进行充分的口腔练习 在牙齿拥挤和旋转的区域保持卫生。 根部接近度 伴随着进入薄齿间骨是有害的， 长期牙周状况。 创伤性闭塞， 齿间或骨骼的差异，削弱牙周组织。 通过治疗牙周病患者的咬合不正， 牙齿健康的预后得到增强，因为治疗是 针对进行性骨丢失的病因。 一个坚实的牙周基础必须存在之前开始 正畸牙齿移动 原始牙周组织的再生 降低了由于正畸导致的有害骨丢失的风险 牙齿移动和增强稳定性的一个 牙列错位 的组合 血小板衍生生长因子和胰岛素样生长因子已经被 显示出增强硬组织和软组织的愈合。 互补 这两种生长因子的作用发生在有丝分裂，细胞 代谢和细胞迁移。 的协同性能， 牙周缺损愈合过程中PDGF/IGF-I的相互作用 在比格犬研究中进行了深入探索。 这项研究将阐明正畸牙齿的影响， 在通过多肽生长再生的牙周组织上的运动 因素 作为第一个目标，将完成一项试点研究， 天然牙牙周组织的再生 发生疾病。 再生后， 将进行牙列检查。 反应的组织学检查 的再生组织的运动将进行;和 与健康牙列中发现的反应进行比较， 正畸牙齿移动将完成。 AIM 2将包括 评估再生模式和对正畸的反应 纵向X线片显示的运动。 顺序标准化 放射线照相术将确定毫米数量的再生， 这些钙化组织的维持或损失作为牙齿移动 进步。 AIM 3将涉及组织标记物的测定 正畸牙移动与牙周组织的关系 再生 这种标记物包括I型、III型、XII型胶原蛋白， 骨钙素、碱性磷酸酶和酸性磷酸酶。 数据 收集的数据将用于探索 牙周组织再生与正畸牙 运动 关键词：牙周组织，再生，正畸牙移动， Beagle犬，血小板源生长因子，胰岛素样生长因子

Malaligned teeth play a major role in the etiology and progression of periodontal disease. Patient have difficulty practicing adequate oral hygiene in areas where teeth are crowded and rotated. Root proximity with accompanying into thin interdental bone are detrimental to long-term periodontal status. Traumatic occlusion, a result of interarach dental or skeletal discrepancies, weakens the periodontium. By treating the malocclusion of a periodontally-compromised patient, the prognosis of the dental health is enhanced, since the treatment is targeted at the etiologic agent of the progressive bone loss. A firm periodontal foundation must be present prior to initiation of orthodontic tooth movement. Regeneration of the original periodontium reduces the risk of detrimental bone loss as a result of orthodontic tooth movement and enhances the stability of a orthodontically-positioned dentition. The combination of platelet-derived growth factor and insulin-like growth factor have been shown to potentiate healing of both hard and soft tissue. Complementary effects of these two growth factors occur in mitogenesis, cell metabolism, and cell migration. The synergistic properties of the PDGF/IGF-I interaction during the healing of periodontal defects have been explored intensively in beagle dog studies. The proposed study will elucidate the effects of orthodontic tooth movement on periodontium regenerated by means of a polypeptide growth factors. As a first aim, a pilot study will be completed to evaluate the regeneration of the periodontium about beagle teeth with naturally occurring disease. Following regeneration, orthodontic movement of the dentition will be performed. Histological examination of the response of the regenerated tissue to the movement will be conducted; and a comparison to the response found in healthy dentition subjected to orthodontic tooth movement will be completed. AIM 2 will consist of evaluating the pattern of regeneration and the response to orthodontic movement by longitudinal radiographs. Sequential standardized radiography will determine the millimeter amount of regeneration and maintenance or loss of these calcified tissues as tooth movement progresses. AIM 3 will involve assaying for tissue markers characteristic of orthodontic tooth movement and periodontium regeneration. This markers include Type I, III, XII collagen, ostecalcin, alkaline phosphatase, and acid phosphatase. The data collected will be used to explore the benefits and limitations of periodontium regeneration in conjunction with orthodontic tooth movement. KEYWORDS: Periodontium, Regeneration, Orthodontic tooth movement, Beagle dog, Platelet-derived growth factor, Insulin-like growth factor