PHARMACEUTICAL RESEARCH CENTER

药物研究中心

• 批准号: 3058700
• 负责人: FREDERICK S HUMPHRIES
• 金额: $ 61.75万
• 依托单位: FLORIDA AGRICULTURAL AND MECHANICAL UNIV
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1995-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3058700
• 关键词: minority institution research support; pharmacy administration

Long term objective: to establish a high level of competitiveness in pharmaceutical research. Specific aims: enhance faculty and student understanding- of, and capability in, proposal preparation; strengthen library holdings to support PhD tracks and research in pharmacology/ toxicology, medicinal chemistry and environmental toxicology; increase animal holding space; provide foundational support for newly hired faculty train minority recipients of PhD, PharmD, DVM, and MD degrees in pharma- ceutical research; develop new potent and safe drugs; and to investigate ethnopharmacological phenomena in certain disease states. Methods. The administrative infrastructure will identify funding opportunities, provide statistical, editorial, graphics, and word processing support, and both internal and external review for proposals. A proposal preparation and grant administration course and a state-of-the-art research seminar series will be established. Basic and supplementary text will be secured to enhance library research. CD-ROM MEDLINE, DIALOG, and National Library of Medicine on-line search capabilities will be provided. State-of-the-art cages will house mice and rats. New research oriented basic science and clinical pharmacy faculty protocols will be evaluated for the merit of requests for foundational general purpose equipment. Minority health science doctoral degree recipients will receive experience and guidance in the conduct of pharmaceutical research. New drugs will be synthesized and screened to determine activity. The bases for ethnic differences in the pharmacokinetics and pharmacodynamics of analgesics, drugs used to treat cancer, and hypertensive agents in elderly African-American and Hispanics will be studied. Restriction fragment length polymorphism techniques will be used to elucidate the molecular basis for ethnic differences in drug response.

长期目标：建立高水平的竞争力， 药物研究。具体目标：提高教师和学生 理解并有能力准备提案;加强 图书馆藏书，以支持博士课程和药理学研究/ 毒理学、药物化学和环境毒理学;增加 动物饲养空间;为新聘教师提供基础支持 培养少数族裔的博士，药学博士，DVM，和医学博士学位在制药- 科学研究;开发新的有效和安全的药物;并调查 某些疾病状态下的民族药理学现象。方法.的 行政基础设施将确定筹资机会， 统计、编辑、图形和文字处理支持，以及两者 对建议书进行内部和外部审查。提案准备和 补助金管理课程和最新研究研讨会系列 将建立。基本文本和补充文本将确保 加强图书馆研究。CD-ROM MEDLINE、DIALOG和美国国家图书馆 将提供在线药物搜索功能。State-of-the-art 笼子里会有老鼠。以新的研究为导向的基础科学和 临床药学教师协议将被评估的优点， 基本通用设备的申请。少数民族健康 科学博士学位获得者将获得经验和指导， 进行药物研究。新的药物将被合成， 筛选以确定活性。民族差异的基础 镇痛药的药代动力学和药效学， 癌症和高血压药物在老年非洲裔美国人和西班牙裔美国人 将被研究。限制性片段长度多态性技术将 用于阐明药物中种族差异的分子基础 反应