NEW THERAPEUTIC APPROACHES FOR MALIGNANT GLIOMA

恶性胶质瘤患者的治疗仍然是一个 挑战. 这项研究计划的目标是开发新的 恶性胶质瘤的治疗方法。 本方案项目 由三个项目和一个核心单位组成。 一个项目是设计 研究不同剂量率对人脑胶质瘤的影响 细胞，并可能导致更好地了解最佳辐射 剂量率单独使用或与化疗联合使用。 一 第二个项目探讨了细胞因子在脑水肿产生中的作用 以及控制脑水肿的可行技术 第三个项目 研究外周型苯二氮卓受体在 恶性肿瘤的增殖、分化和细胞周期动力学 胶质瘤及其与化疗和细胞因子的潜在相互作用。 核心单位将负责建立和维护 恶性胶质瘤细胞系。 此外，核心单位还将 收集患者的脑肿瘤样品，从肿瘤中分离DNA和RNA， 并从患者的肿瘤中获得分子遗传数据， 细胞系 总之，这些调查可能会导致改善 目前治疗恶性胶质瘤的疗效，同时减少 潜在的神经毒性 这些项目沿着 我们中心的潜在优势构成了发展的基础， 脑肿瘤研究中心

The treatment of patients with malignant glioma continues to be a challenge. The goal of this research program is to develop new therapeutic approaches for malignant glioma. This program project consists of three projects and one core unit. One project is designed to study the effects of variation of radiation dose rates on human glioma cells and may lead to a better understanding of the optimal radiation dose rate to use either alone or when combined with chemotherapy. A second project explores the role of cytokines in producing brain edema and possible techniques to control brain edema. The third project investigates the role of peripheral-type benzodiazepine receptors in the proliferation, differentiation, and cell cycle kinetics of malignant glioma and their potential interactions with chemotherapy and cytokines. The core unit will be responsible for establishing and maintaining malignant glioma cell lines. In addition, the core unit will also collect brain tumor samples from patients, isolate DNA and RNA from tumor and obtain molecular genetic data from patients' tumors as well s their cell lines. Together, these investigations may lead to improvement in the efficacy in current treatment for malignant glioma while reducing potential neurotoxicity from therapy. These projects along with the potential strengths of our Center form the basis for the development of a Brain Tumor Research Center.