AUTOIMMUNE PHENOMENA IN SCHIZOPHRENIA

自身免疫机制已被描述为许多中枢神经系统疾病 全身性疾病，而且有研究表明，精神分裂症 他们有几个临床、流行病学和遗传学特征。 系统性红斑狼疮等疾病的典型免疫指标异常 红斑症、多发性硬化症和类风湿性关节炎也 在精神分裂症中表现出来，并提供了另一种间接联系 精神分裂症和自身免疫性疾病。搜索的历史 然而，对于精神分裂症的免疫学圣痕来说， 有争议的一个，有一些有趣的发现，但都失败了 来寻找复制。现行修订后的小额助学金申请 类别是一种试图显示和关联异常血清和脑脊液的方法 白介素性水平、CD5+B细胞增加和抗脑抗体 同一组72名住院精神分裂症患者。 双相情感障碍患者和健康人将被研究为 控制。血清催乳素和抗精神病药对高血压病患者的影响 将检查免疫措施。在修订后的呈件中，重点是 放在努力检查更大样本的患者和 精神控制来扩展我们之前的发现40% 被研究的精神分裂症患者血清中抗60- 千道尔顿PI线粒体热休克蛋白。与此相关的研究 其他假定的自身免疫参数的具体发现将是 承担了。据推测，许多这样的事件同时发生 精神分裂症患者同一亚组的自身免疫相关研究 这一试点项目中的患者将支持自身免疫的理论 并对今后的研究方向提出了建议。

Autoimmune mechanisms have been described for a number of central nervous system diseases, and it has been suggested that schizophrenia shares several clinical, epidemiological, and genetic characteristics with them. Abnormal immunologic measures typical of diseases such as systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis have also been demonstrated in schizophrenia and provide another indirect link between schizophrenia and an autoimmune pathogenesis. The history of the search for immunological stigmata in schizophrenia, however, has been a controversial one, with a number of intriguing findings which have failed to find replication. The present Revised Application in the SMALL GRANT category is an attempt to demonstrate and correlate aberrant serum and CSF interleukin levels, increased CD5+ B Cells, and anti-brain antibodies in the same group of seventy-two hospitalized schizophrenic patients. Patients with bipolar disorder and healthy individuals will be studied as controls. The effects of serum prolactin and neuroleptic medication on the immunologic measures will be examined. In the revised submission, focus is placed on the efforts to examine a larger sample of patients and psychiatric controls to extend our previous finding that 40% of schizophrenic patients studied had serum IgG antibodies to the 60- kilodalton PI mitochondrial heat shock protein. Studies to correlate this specific finding with other putative autoimmune parameters will be undertaken. It is hypothesized that the co-occurrence of a number of such autoimmune-associated findings in the same subgroup of schizophrenic patients in this pilot project would support a theory of autoimmune pathogenesis and would suggest directions for future research.