25TH ANNUAL INTERNATIONAL NARCOTICS RESEARCH CONFERENCE

此应用程序请求为美国科学家提供旅行支持 筹划参加第25届国际经济合作组织年会 毒品研究会议(INRC)。这次会议将举行 1994年7月16日至21日，在马萨诸塞州科德角北法尔茅斯的海峰举行。 它是由项目主席埃里克·西蒙博士组织的，他领导一个 当地组委会。意见由INRC秘书提供( Co-Pi，H.Akil)和负责监督该计划的INRC执行委员会 在年度会议内部和之间保持平衡。这次会议一直是 初步被批准为国际药理学卫星 蒙特利尔会议(IUPHAR)。 1994年的INRC会议肯定会特别激动人心。克隆人 1992年底第一个阿片受体(Delta型)的发现开启了 用于鉴定和鉴定其他阿片受体的门 类型和子类型。几个实验室一直在积极研究 这方面的研究。Kappa受体已被克隆到几个 多个实验室的物种，以及它们异质性的初步证据 已经出现了。三角洲非均质性的平行研究包括 正在进行中。据我们所知，Mu受体家族的一名成员还没有 尚未完全确定，但在可预见的时间内，这种情况可能会发生变化 未来。因此，1994年的会议将是INRC的第一次会议 受体异质性的问题可以在 根据分子生物学数据。这将是至关重要的评估 结构、药理、生理、行为和临床 这些发现的含义。在许多方面，最近的事态发展 将有助于重新规划该领域多个领域的研究进程。 此外，还有一些新的概念、突破和新颖 在阿片类药物研究的其他领域使用的研究战略，范围 从阿片肽基因表达的分子生物学到新的 对阿片类药物耐受性和依赖性的看法，到关于 阿片类药物系统的激励方面。INRC会议是一个理想的会议 确保这些想法将得到彻底评估和 年轻的科学家将参与到这些活动中来 讨论。 差旅资金将根据明确的层次结构进行分配 优先事项，初级科学家优先考虑。一个 补助金的一部分将专门用于支持科学研讨会 在会议上，一小部分将用于行政和 支付旅费和支持出版 法律程序。

This application requests travel support for United States scientists planning to participate in the 25th Annual Meeting of the International Narcotic Research Conference (INRC). This conference will take place July 16-21, 1994 at Sea Crest in North Falmouth, Cape Cod, Massachusetts. It is being organized by Dr. Eric Simon, the Program Chair, heading a Local Organizing Committee. Input is provided by the INRC Secretary (the Co-PI, H. Akil) and the INRC Executive Committee, which oversees program balance within and across annual conferences. This conference has been tentatively approved as a satellite of the International Pharmacology Meeting (IUPHAR) in Montreal. The 1994 INRC meeting promises to be particularly exciting. The cloning of the first opioid receptor (delta type) in late 1992 has opened the door for the identification and characterization of other opioid receptor types and subtypes. Several laboratories have been vigorously pursuing research in this area. Kappa receptors have been cloned in several species by multiple labs, and preliminary evidence of their heterogeneity has already emerged. Parallel investigations of delta heterogeneity are underway. To our knowledge, a member of the mu receptor family has not been fully identified yet, but this will likely change in the foreseeable future. Thus, the 1994 Meeting will represent the first INRC meeting where the issue of receptor heterogeneity can be fully reexamined in light of molecular biological data. It will be critical to evaluate the structural, pharmacological, physiological, behavioral and clinical implications of these findings. In many ways, the recent developments will help re-chart the course of research in several areas of this field. Furthermore, there are a number of new concepts, breakthroughs and novel research strategies being used in other areas of opioid research, ranging from the molecular biology of opioid peptide gene expression, to novel views of opiate tolerance and dependence, to new concepts regarding the motivational aspects of opioid systems. The INRC meeting is an ideal vehicle to ensure that these ideas will be thoroughly evaluated and discussed, and that young scientists will participate in these discussions. Travel funds will be dispersed according to a well defined hierarchy of priorities, with junior scientists being given first preference. A portion of the grant will be earmarked for supporting scientific symposia at the meeting, and a small amount will be used for administration and disbursement of travel funds and in support of publication of the proceedings.