EVOLUTION OF HUMAN HEPATITIS B VIRUS PRECORE VARIANT

我的长期职业目标是利用分子和细胞生物学 研究细胞分化和生长控制的工具， 肿瘤发生的动物病毒模型。 我的职业目标是 确定参与的机制，并制定临床 人B型肝炎病毒相关性肝损害的干预措施 肿瘤发生 在我的职业生涯中，我很幸运能够在 与麻省理工学院、哈佛大学、宾夕法尼亚大学和UTMB的许多杰出科学家一起， 加尔维斯顿。 我选择来UTMB的部分原因是- 加尔维斯顿是休斯顿最好的学术氛围- 加尔维斯顿地区。 MD安德森之间的便捷互动 医院，贝勒学院，莱斯大学，休斯顿大学， UTMB-Galveston及其附属医院一直非常 吸引了许多年轻科学家。 我发现UTMB-Galveston 是一个非常愉快和刺激的地方，这将使我能够 与许多友好和足智多谋的同事，如博士互动。 大卫步行者，奥布里汤普森，布拉德汤普森，塞缪尔威尔逊，迈尔斯 作者声明：by J. 虽然这种环境对年轻科学家来说是一个很好的利基， 建立一个独立的职业生涯，这一因素本身可能不是 足够了。 在过去的几年里，在宾夕法尼亚大学，我经常被 由于许多非研究义务和 学习granulate。 一旦RCDA被授予，我们的部门 UTMB的主席向我保证，他将减少我的教学， 将行政责任降至最低。 人B型肝炎病毒（HBV）的慢性感染是一种主要的 肝癌的病因 最近，一种HBV变异体， HBV前C序列内的热点突变已经被 从一个重要的慢性亚群的血清中鉴定出 肝炎患者。 简单地逃避免疫监视 解释这些基因突变的高频率发生， 热点 一些关于潜在的假设 这些前核心变体相对于野生型的选择性优势 将在组织培养系统中测试病毒。

My long term career goal is to use molecular and cellular biology tools to investigate cell differentiation and growth control in an animal virus model of oncogenesis. My immediate career goal is to determine the mechanisms involved in, and develop clinical interventions for, human hepatitis B virus associated hepatic oncogenesis. Throughout my career, I have been very fortunate to be able to work with many outstanding scientists at MIT, Harvard, Penn and UTMB- Galveston. Part of the reason that I chose to come to UTMB- Galveston is the favorable intellectual climate in the Houston- Galveston area. The convenient interactions among MD Anderson Hospital, Baylor college, Rice University, University of Houston, UTMB-Galveston and their affiliated hospitals have been very appealing to many young scientists. I have found UTMB-Galveston to be a very pleasant and stimulating place which will enable me to interact with many friendly and resourceful colleagues such as Drs. David Walker, Aubrey Thompson, Brad Thompson, Samuel Wilson, Miles Cloyd, Samuel Baron, John Papaconstantinou. Although this environment is a good niche for a young scientist to establish an independent career, this factor alone may not be sufficient. Over the past few years at Penn, I have often been sidetracked by numerous non-research obligations and the ordeal of learning grantsmanship. Once an RCDA is awarded, our Department Chairman at UTMB assures me he will reduce my teaching and administrative responsibilities to a minimum. Chronic infection with human hepatitis B virus (HBV) is a major cause of liver cancer. Most recently, one HBV variant with a hotspot mutation within the precore sequences of HBV has been identified from the sera of a significant subset of chronic hepatitis patients. A simple escape from immunosurveillance cannot explain the high frequency occurrence of mutations at these hotspots. A number of hypotheses concerning the potential selective advantage of these precore variants over the wild type virus will be tested in a tissue culture system.