The Systems Biochemistry of Adaptation in Cellular Protein Networks

细胞蛋白质网络适应的系统生物化学

• 批准号: FT190100645
• 负责人: Dr Robyn Araujo
• 金额: $ 51.4万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-02-24 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT190100645
• 关键词: Systems; Biochemistry; Adaptation; Cellular; Protein

A living cell must process and interpret a host of diverse signals using a complex network of interacting proteins inside the cell. The detailed molecular mechanisms by which cells exhibit adaptation to these signals remains a fundamental question in biology. This project aims to develop a novel mathematical framework for analysing the capacity of intracellular protein interactions to contribute to cellular adaptation, along with a novel methodology for validating mathematical models against experimental data. These innovations offer a completely fresh approach to identifying and modulating the adaptive capacities of living cells, which may contribute to overcoming the problem of drug resistance in future therapeutic development.

活着的细胞必须使用细胞内相互作用的蛋白质的复杂网络来处理和解释一系列不同的信号。细胞对这些信号表现出适应的详细分子机制仍然是生物学中的一个基本问题。该项目旨在开发一种新的数学框架，用于分析细胞内蛋白质相互作用促进细胞适应的能力，以及一种用于根据实验数据验证数学模型的新方法。这些创新为识别和调节活细胞的适应能力提供了一种全新的方法，这可能有助于在未来的治疗开发中克服耐药性问题。