The Systems Biochemistry of Adaptation in Cellular Protein Networks

活细胞必须使用细胞内相互作用的蛋白质的复杂网络来处理和解释大量不同的信号。 细胞对这些信号表现出适应的详细分子机制仍然是生物学中的一个基本问题。 该项目旨在开发一种新的数学框架，用于分析细胞内蛋白质相互作用的能力，以促进细胞适应，沿着一种新的方法，用于验证数学模型对实验数据。 这些创新提供了一种全新的方法来识别和调节活细胞的适应能力，这可能有助于克服未来治疗开发中的耐药性问题。

A living cell must process and interpret a host of diverse signals using a complex network of interacting proteins inside the cell. The detailed molecular mechanisms by which cells exhibit adaptation to these signals remains a fundamental question in biology. This project aims to develop a novel mathematical framework for analysing the capacity of intracellular protein interactions to contribute to cellular adaptation, along with a novel methodology for validating mathematical models against experimental data. These innovations offer a completely fresh approach to identifying and modulating the adaptive capacities of living cells, which may contribute to overcoming the problem of drug resistance in future therapeutic development.