STRUCTURE AND REACTIONS OF COORDINATED QUINONES

配位醌的结构和反应

• 批准号: 2189393
• 负责人: JOSEPH HAJDU
• 金额: $ 10.63万
• 依托单位: CALIFORNIA STATE UNIVERSITY NORTHRIDGE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-18 至 1998-09-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2189393
• 关键词: cadmium; chemical kinetics; chemical property; chemical reaction; chemical structure; chemical synthesis; cofactor; electrochemistry; electron spin resonance spectroscopy; hydroxyl radical; metal complex; nuclear magnetic resonance spectroscopy; oxidation reduction reaction; quinones; semiquinone; superoxides; temperature; zinc

DESCRIPTION: Quinoenzymes are a widely distributed class of oxidoreductases with quinone cofactors that frequently occur with metal ions as part of catalytically functional redox active complexes. Metal- quinone complexes have also been implicated in the mechanism of action of pharmacologic agents, including antitumor antibiotics. The proposed project aims at the structural characterization and mechanistic elucidation of syntheticquinone-metal complexes designed as bioorganic models for understanding the mechanism of action of biologically active metal-quinone complexes. Through the use of optical spectroscopy, proton and 13C-NMR techniques as well as ESR methods, the structural and chemical properties of the complexes will be delineated. The redox chemistry will be developed using electrochemical methods as well as chemical reducing and oxidizing agents. The structural and chemical properties of semiquinone radicals and their metal complexes will be determined with these methods, and kinetic studies. The experiments outlined will focus on delineating the role of metal ions in influencing the reactivity of the redoxactive ligand including generation and characterization of the semiquinone intermediates. It will provide preliminary results toward the design of a more comprehensive research project on the structure and reactivity of p-quinone metal complexes.

描述：奎宁酶是一类广泛分布的 具有醌辅因子的氧化还原酶，经常与金属 离子作为催化功能氧化还原活性络合物的一部分。金属- 醌络合物也与作用机制有关 包括抗肿瘤抗生素在内的药物制剂。拟议 该项目的目的是结构表征和机械 生物有机合成醌金属配合物的研究 了解生物活性物质作用机制的模型 金属-醌络合物通过使用光谱学，质子 和~（13）C-NMR技术以及ESR方法， 将描述络合物的化学性质。氧化还原 将使用电化学方法开发化学， 化学还原剂和氧化剂。结构和化学 半醌自由基及其金属络合物的性质将是 用这些方法测定，和动力学研究。实验 概述将侧重于描绘金属离子的作用， 氧化还原活性配体的反应性包括生成和 半醌中间体的表征。它将提供 初步成果朝向设计更全面的研究 对苯醌金属配合物的结构和反应性项目。