Programmed cell death signalling in innate immunity

先天免疫中的程序性细胞死亡信号传导

• 批准号: FT190100266
• 负责人: A/Prof Kate Lawlor
• 金额: $ 54.02万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-28
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT190100266
• 关键词: Programmed; cell; death; signalling; innate

This proposal aims to address the under-explored potential for programmed cell death to promote innate immune cell signalling, which is a critical and fundamental biological process. It aims to generate new knowledge in the areas of cell death and innate signalling using innovative interdisciplinary approaches and discover new molecules that impact innate inflammatory responses. The expected outcomes of this project are to enhance our basic understanding of cell death, and build interdisciplinary collaborations. This work should provide significant benefit to the economy and health of Australians, as it is expected to identify molecules that will be of interest to the pharmaceutical and biotechnology industries.

该提案旨在解决未充分开发的程序性细胞死亡潜力，以促进先天免疫细胞信号传导，这是一个关键和基本的生物学过程。它旨在使用创新的跨学科方法在细胞死亡和先天信号传导领域产生新的知识，并发现影响先天炎症反应的新分子。该项目的预期成果是加强我们对细胞死亡的基本理解，并建立跨学科合作。这项工作将为澳大利亚人的经济和健康带来重大利益，因为预计它将确定制药和生物技术行业感兴趣的分子。