GORDON CONFERENCE ON FIBRONECTIN, INTEGRINS & RELATED MA

纤维连接蛋白、整合素戈登会议

• 批准号: 2082809
• 负责人: Jean E Schwarzbauer
• 金额: $ 1.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-01-20 至 1995-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2082809
• 关键词: cell adhesion molecules; fibronectins; integrins; meeting /conference /symposium; travel

Funds are requested for a Gordon Conference on fibronectin, integrins, and related macromolecules to meet in Oxnard, California, in February 1995. The paradigm of an extracellular adhesin, fibronectin interaction with a transmembrane receptor has proven applicable to a number of adhesion systems. There are several other extracellular glycoproteins with biological properties like fibronectin including laminin, thrombospondin, von Willebrand factor, fibrinogen/fibrin, vitronectin, and cytotactin/ tenascin/hexabrachion. The primary structures of each of these proteins are determined and three-dimensional structures are available for parts of some. This will open up new possibilities for studies of function. In parallel has come the realization that the transmembrane receptor for fibronectin is only one member of the integrin family of functionally related, homologous, cell adhesion receptors. Fibronectin and related macromolecules are involved in many basic functions of cells, including cell adhesion, determination of cell shape and differentiation, cell migration, cytoskeletal organization, and organization of extracellular matrix. Thus, fibronectin and the molecules with which it interacts are important in embryogenesis, connective tissue organization, hemostasis, thrombosis, wound healing, development of immunity, hematopoiesis, malignant transformation, and tumor metastasis. The challenges to the field over the next several years are to comprehend and organize the large amount of new structural information and design experiments based upon it; learn the relative biological importance of the several seemingly redundant adhesion systems; and apply the new insights to the treatment of human diseases. The 1995 Gordon Research Conference will serve as a valuable forum to present and discuss new information, identify problem areas, and plan new approaches.

要求为关于纤维连接蛋白、整合素和 1995年2月在加州的奥克斯纳德举行会议。 细胞外粘附素、纤连蛋白与 跨膜受体已被证明适用于许多粘附 系统.还有几种其他的胞外糖蛋白， 生物学性质如纤连蛋白，包括层粘连蛋白，血小板反应蛋白， 血管性血友病因子、纤维蛋白原/纤维蛋白、玻连蛋白和胞浆素/ tenascin/hexabrachion。这些蛋白质的一级结构 的部分确定和三维结构是可用的 一些.这将为功能研究开辟新的可能性。 在 与此同时，人们认识到， 纤连蛋白仅是功能性整合素家族的一个成员， 相关的同源的细胞粘附受体。 纤连蛋白及相关 大分子参与细胞的许多基本功能，包括 细胞粘附，细胞形态和分化的测定，细胞 迁移、细胞骨架组织和细胞外 矩阵因此，纤连蛋白及其相互作用的分子是 在胚胎发生、结缔组织组织形成、止血 血栓形成，伤口愈合，免疫力的发展，造血， 恶性转化和肿瘤转移。面临的挑战 在未来几年内，该领域将理解和组织大型 大量新的结构信息和基于此的设计实验; 了解几个看似重要的生物学特征， 多余的粘附系统;并将新的见解应用于治疗 人类疾病。1995年戈登研究会议将作为一个 提供和讨论新信息、确定问题 #21453;，并规划新的方法。